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Claire Nissenbaum
Specialty Trainee Paediatric Respiratory Medicine
Manchester
Public Documents
1
T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS
Aida Semic-Jusufagic
and 7 more
March 08, 2022
We describe a case of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) to multiple CFTR modulators and piperacillin in an 8 year old female with CF. To our knowledge this is the first reported case of delayed type, T-cell mediated hypersensitivity to multiple CFTR modulators described in literature. Our findings suggest possible cross-reactivity between CFTR modulators or multiple sensitisations, which should be taken into account in similar cases.