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Horror Movies: A trigger for PTSD and Anxiety
Nathalie Akiki
Malak Wehbe

Nathalie Akiki

and 2 more

March 31, 2023
Horror movies have been produced, filmed and broadcasted for decades. It has been thought that people watching such movies, tend to get influenced by harsh scenes, leading to psychological distress. This review highlights the impact of horror movies in developing post-exposure reactions, such as Post Traumatic Stress Disorder, and anxiety and discusses the different risk factors and mechanisms behind such manifestations.
A Qualitative Study of Military Service Members Undergoing Medical Separation
Marjan Ghahramanlou Holloway
Su Yeon Lee-Tauler

Marjan Ghahramanlou Holloway

and 12 more

March 31, 2023
Objective: A qualitative study sought to understand the transition experiences of United States (U.S.) military Service members found “unfit for duty” following medical and physical evaluation boards (MEBs and PEBs). Methods: Confidential telephone interviews were conducted with 25 current and prior Service members. Participants were asked to share their experiences before, during, and after the MEB and PEB processes. To that end, interview questions were designed to gather the following types of transition experiences: (1) health conditions experienced during the medical disability evaluation process; (2) reactions to being recommended for separation, (3) transition-related stress and challenges, and (4) coping strategies. Salient themes were identified across chronological narratives. Results: Conditions that participants’ experienced included debilitating physical (e.g., injury) and/or mental health (e.g., post-traumatic stress disorder) conditions. In response to the “unfit for duty” notice, some participants reported emotional distress (e.g., anxiety, sadness, anger) connected to a sense of uncertainty about the future. Other participants reported relief connected to a sense of progression toward their medical disability claim status. Transition stress included the length of the MEB/PEB process, impact of the COVID-19 pandemic on the process, experiences of financial stress, impact on family life, and the compounded effect of these stressors on emotional distress, including depression and suicidal thoughts. Participants reported using adaptive (e.g., psychotherapy) and maladaptive (e.g., excessive drinking) strategies to cope with stress. Conclusions: The notable emotional distress and transition stress experienced by Service members found “unfit for duty” highlight the need for increased support and interventions to facilitate adaptive coping strategies during this vulnerable period.
A Review on Machine Process Parameters of Laser Engineered Net Shaping
Tamiru  Hailu Kori
Dawit Muluneh Yona

Tamiru Hailu Kori

and 3 more

March 31, 2023
Manufacturing sectors are shifting their interest toward additive manufacturing technologies, where components are fabricated directly from CAD models layer by layer. Laser engineered net shaping most known to produce a near net shape of functionally graded materials. In this paper, process parameters that affect mechanical properties, surface topology and physical properties are reviewed. Powder feed rate, hatch distance and layer thickness more related to porosity of the parts that being produced. Mechanical properties get affected by laser power scan speed. Density and hardness sensitive to focal distance of the optimal convergence of the maximal laser intensity and the localized spatial concentration of the powder beam. To get homogeneous microstructure shorter focal distance is preferable. However, working distance has no such impact on density.
A Case Report: The First Show Phenomenon In The Treatment Of Spinal Cord Injury With...
Rita Boulos
lea nemer

Rita Boulos

and 5 more

March 31, 2023
A Case Report: The First Show Phenomenon In The Treatment Of Spinal Cord Injury With Regentime Procedure Using Autologous Bone Marrow-Derived Stem CellsRita T. Boulos a†, Lea I. Nemerb†, Vanessa J. Mansour c†, Cynthia F. Najjoumd††,Elsa A. Asmar e†† and Nassim H. Abi Chahinef*† Authors’ equal contribution†† Authors’ equal contributionStem Cell Transplantation/Neurology, ACE Cells Lab Limited, Beirut, LBStem Cell Transplantation/Molecular Biology, ACE Cells Lab Limited, Beirut, LBStem Cell Transplantation/Infectious Diseases/Immunology, ACE Cells Lab Limited, Beirut, LBStem Cell Transplantation/Infectious Diseases/Immunology, ACE Cells Lab Limited, Beirut, LBStem Cell Transplantation/Functional Genomics/Proteomics, ACE Cells Lab Limited, Beirut, LBStem Cell Transplantation/Neurological Surgery, ACE Cells Lab Limited, Beirut, LB* Correspondence to:Dr. Nassim H. Abi ChahineTel: +9613082498E-mail: info@regentime.com
Spherocytosis in Newborn Secondary to Novel Heterozygous Mutation in SPTB Gene
Daphna Varadi
Benjamin Caplan

Daphna Varadi

and 3 more

March 31, 2023
This case report describes a novel mutation of the SPTB gene as a potential pathogenic cause of spherocytosis. A three-week-old male presented with clinical and laboratory signs consistent with hemolytic spherocytosis (HS), including jaundice, hyperbilirubinemia, anemia, reticulocytosis, negative Coombs test, no ABO or Rh incompatibility, and a peripheral blood smear notable for numerous spherocytes. His lab work demonstrated persistent anemia despite daily folate prompting next-generation sequencing (NGS) which revealed a novel mutation in the SPTB gene resulting in a non-functioning protein product. Correlation of the genetic finding with clinical presentation may help guide management for this and future patients.
Is Smoke the Signal for Surgery? : Should the Moyamoya Syndrome “Puff of Smoke” trigg...
Lewis Hsu

Lewis Hsu

March 31, 2023
Stroke in Sickle Cell Revascularization Surgery Retrospective Study (SiSCRS) in this issue reports retrospective data from 15 medical centers to examine the benefit of cerebral revascularization surgery (CRS) in children with sickle cell disease (SCD) who also have Moyamoya Syndrome (SCD-MMS). The American Society of Hematology guidelines “suggests evaluation for revascularization surgery in addition to regular blood transfusion” for treating SCD-MMS combined with a history of stroke or transient ischemic attack but categorizes this as a “conditional recommendation based on very low certainty in the evidence about effects”. The research presented in this article is aimed at reducing the uncertainty surrounding revascularization surgery as a treatment using retrospective data from 15 medical centers with expertise in CRS for SCD-MMS. Even with the 78 children with CRS (Surgery group) and 63 children in the non-surgery (Conservative group), the differences between the two groups had mixed statistical significance in multivariate analyses. SiSCRS is an important retrospective analysis but must be interpreted with caution. The benefit of CRS attains statistical significance only in some of the comparisons. The rate of stroke in pediatric SCD decreases with age, creating a bias in favor of the older group (i.e., the Surgery Group) to have fewer CVEs, The additional role of aspirin and the bias of patient selection for surgery also weaken the ability to make definitive statements. The SiSCRS results suggest a likely retrospective benefit of CRS, but the benefit must be demonstrated with more rigorous studies in the future.
Mechanism of Acute Pacing Threshold Elevation During Simultaneous Micra Leadless Pace...
Racine HP
Nicolas Dognin

Racine HP

and 6 more

March 31, 2023
Background In patients with refractory atrial fibrillation (AF), atrioventricular nodal (AVN) ablation and permanent pacemaker implantation is recommended. The Micra Transcatheter Pacing System™ (Micra) is a single chamber leadless pacemaker (LPM) and thus offers the possibility of AV node (AVN) ablation in the same procedure. Pacing threshold (PT) elevation after radiofrequency (RF) ablation is a potential complication. Methods We conducted a single center retrospective cohort study. All patients implanted with a Micra (n=84) and concomitant or delayed AVN ablation (n=12) from 2014 to 2022 were included. We describe two cases of acute Micra PT elevation immediately following RF AVN ablation requiring device retrieval and implantation of a new Micra. Procedural characteristics and electrophysiological parameters were analyzed, and computer modelling was performed to determine factors responsible for acute PT elevations. Results A total of 84 patients were included. Mean age was 74±10 and 48% were women. Twelve patients (14%) underwent AVN ablation. Two patients had acute PT elevation requiring device retrieval despite no direct contact of the ablation catheter with the Micra. Computer modelling shows that significant dissipated power due to electrical field coupling can occur at the tip or ring electrode if the catheter is not kept at a safe distance (≥15 mm) from the Micra. Conclusion Concurrent AVN ablation and Micra implantation is safe in most patients. To prevent acute PT elevation, keeping a safe distance of ≥15 mm from the tip and ring electrodes of the Micra and using lower power output may prevent this complication.
GINGIVAL NEUROFIBROMA IN NON SYNDROMIC NEUROFIBROMATOSIS TYPE 1
homeira saebnoori
ASOMA AWUDU

homeira saebnoori

and 1 more

March 31, 2023
Neurofibromatosis type 1 may present as a gingival neurofibroma in a patient with no family history. Accurate diagnosis will lead to successful management of oral lesions. The present case is a report of sporadic gingival neurofibroma in an 18 year old male.
Electrocardiographic characteristics of ventricular arrhythmias originating from diff...
lin jia-feng
Yifan Lin

lin jia-feng

and 7 more

March 31, 2023
Background: This study aimed to explore the electrocardiographic (ECG) characteristics of ventricular arrhythmia (VA) arising from epicardial and endocardial areas adjacent to mitral annual (MA). Methods: This study involved 283 patients with MA-VA who received radiofrequency catheter ablation at the center. The ECG characteristics of these patients were analyzed retrospectively. Results: The origin of MA-VA was judged based on the ECG variables. Among all MA-VAs, IDT > 77 ms or MDI > 0.505 predicted the VAs arising from epicardium (sensitivity of 70.20% and 73.51%, specificity of 94.70% and 82.58%, positive predictive value (PPV) of 93.81% and 82.84%, and negative predictive value (NPV) of 73.53% and 73.15%). Among all epicardial MA-VAs, the RV1/RV2 ratio > 0.87 predicted the VAs originating from the epicardial anteroseptal wall adjacent to MA. It had sensitivity, specificity, PPV, and NPV of 62.86%, 98.06%, 91.67%, and 88.60%, respectively. Among all endocardial MA-VAs, Q(q)R(r) morphology in lead V1 predicted the VAs arising from the endocardial septal wall adjacent to MA. It had sensitivity, specificity, PPV, and NPV of 92.98%, 100%, 100%, and 94.94%, respectively. Among all endocardial septal MA-VAs, a predominant positive wave in lead II and a predominant negative wave in lead III predicted the VAs arising from the endocardial mid-septal portion adjacent to MA. It had sensitivity, specificity, PPV, and NPV of 86.04%, 100%, 100%, and 70.00%, respectively. Conclusion: ECG characteristics of VAs from the different sites adjacent to MA can judge the arrhythmia’s origin and design the ablation plan accordingly.
Whole bowel irrigation should not be used routinely in the management of poisoned pat...
Euan Sandilands

Euan Sandilands

March 31, 2023
Whole bowel irrigation is a method of gastric decontamination in the poisoned patient involving administration of large volumes of osmotically balanced polyethylene glycol-electrolyte solution to empty the gastrointestinal tract of ingested toxins before absorption, limiting systemic toxicity. While this approach may seem intuitive and it can lead to expulsion of tablets or packets in the rectal effluent, there is a lack of evidence correlating this with improved patient outcomes. Administration of whole bowel irrigation is also challenging to the inexperienced physician and associated with adverse effects, which may be serious. Recommendations for the consideration of whole bowel irrigation are limited to patients who have ingested modified release preparations, those of have ingested pharmaceuticals not adsorbed by activated charcoal, and for the removal of packages in body packers. Until more robust evidence is available from high-quality prospective studies demonstrating efficacy, the use of whole bowel irrigation should not be used routinely in poisoned patients.
A novel high-efficiency multi-layer carbon/polyester cotton fabric vaporizer and its...
Jiugang Li
Jiahao He

Jiugang Li

and 6 more

March 31, 2023
Solar-driven evaporation of seawater by the photothermal materials (PM) is considered to be a promising strategy to solve the global water shortage. Fiber-based photothermal material is one of the most important PM materials. However, traditional single-layer fabrics have the demerits of heat-losses and salt-crystallize on the evaporation zone during the long-term seawater desalination, which significantly reduces the evaporation rate of the products. Herein, a novel three-layered 3D spacer carbon/polyester cotton spacer woven fabric (SWF) evaporator is designed. This novel SWF consist of a top water evaporate layer, a middle water transfer/thermal insulation/salt crystal layer and a bottom water absorption layer. The above rational three-layered 3D structure guarantees the fast water-transformation of SWF evaporator while avoid the heat loss from the top layer. The evaporation rate of 3D SWF with 6 mm interval space reaches 2.1 kg·h-1·m-2 in a solar-wind (1 kW·m−2, 2 m·s-1) coupled field, which is proved to be competent for the actual seawater desalinate application.
Entry and leaving arcs of turnpikes: their exact computation in the calculus of varia...
Pedro Fortuny Ayuso
Luis Bayon

Pedro Fortuny Ayuso

and 3 more

March 31, 2023
We settle the question of how to compute the entry and leaving arcs for turnpikes in autonomous variational problems, in the one-dimensional case using the phase space of the vector field associated to the Euler equation, and the initial/final and/or the transversality condition. The results hinge on the realization that extremals are the contours of a well-known function and that that the transversality condition is (generically) a curve. An approximation algorithm is presented and an example included for completeness.
Frequency and burden of disease for SARS-CoV-2 and other viral respiratory tract infe...
Marie Latouche
Mahdi Ouafi

Marie Latouche

and 6 more

March 31, 2023
Background: To evaluate the frequency and burden of disease of SARS-CoV-2 and other respiratory viruses in children under the age of 2 months. Methods: A retrospective, cross-sectional, single-center study was conducted between March 2021, and February 2022. All children under the age of 2 months and tested for SARS-CoV-2 were included. The frequency of SARS-CoV-2, of other respiratory viruses and the burden of disease caused by SARS-CoV-2 and other respiratory viruses were evaluated. Results: 727 children with an RT-PCR test for SARS-CoV-2 were included (mean age: 0.9 months (±0.6); boys: 57%); 514 (71%) in the emergency room and 213 (29%) in hospital. Among them, 62 (8.5%) had a positive RT-PCR test for SARS-CoV-2, more often in the Omicron period (23%) than in the Alpha period (4%). Of the 565 (78%) with a multiplex RT-PCR test for other viruses, 325 (58%) were positive. Children with a positive SARS-CoV-2 were less likely to have required respiratory support (p=.001), enteral nutrition (p=.03), or intensive care admission (p=.01) and had a shorter hospital stay than children with other respiratory viruses (5d vs. 7d, p=.007). Conclusion: In this young population of children, SARS-CoV-2 infection was less frequent and less severe than other viral respiratory infections.
Non-fragile containment control of nonlinear multi-agent systems via a disturbance ob...
Tuo Zhou
Quanli Liu

Tuo Zhou

and 2 more

March 31, 2023
In this paper, we consider the non-fragile containment control problem of nonlinear multi-agent systems (MASs) with exogenous disturbance where the communication links among agents under consideration is directed. Firstly, based on relative output measurements between the agent and its neighbors, a disturbance observer-based control protocol is proposed to solve the containment control problem of MASs with inherent nonlinear dynamics and exogenous disturbances. Secondly, because of the additional tuning of parameters in the real control systems, uncertainties in the designing of observer and controller gains always occur, and as a result, an output feedback controller with disturbance rejection is conceived and the containment control problem of nonlinear MASs with non-fragility is thoroughly investigated. Then, depending on matrix transformation and inequality technique, sufficient conditions of the designed controller gains exist, which is derived from the asymptotic stability analysis problem of some containment error dynamics of MASs. Finally, two simulation examples are exploited to illustrate the effectiveness of the proposed techniques.
Long-term prognosis after low-dose peanut challenge for patients with history of anap...
Nobuko Akamatsu
Ken-ich  Nagakura

Nobuko Akamatsu

and 4 more

March 31, 2023
Long-term prognosis after low-dose peanut challenge for patients with history of anaphylaxisNobuko Akamatsu, MD, PhD1,2, Ken-ichi Nagakura, MD, PhD1, Sakura Sato, MD3, Noriyuki Yanagida, MD, PhD1,3,*, Motohiro Ebisawa, MD, PhD3 1Department of Pediatrics, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan2Department of Pediatrics and Adolescent Medicine, Tokyo Medical University Hospital, Tokyo, Japan3Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, JapanRunning title: Prognosis after low-dose peanut challenge*Corresponding author: Noriyuki Yanagida, MD, PhDDepartment of Pediatrics, National Hospital Organization, Sagamihara National Hospital,18-1, Sakuradai, Minami-ku, Sagamihara, Kanagawa 252-0392, JapanE-mail: yana@foodallergy.jpWord count: 1190Number of figures: 2 Number of tables: 0Conflict of interest: Motohiro Ebisawa and Sakura Sato have received speaker honoraria from Viatris. All other authors declare that they have no conflicts of interest.Financial support: This paper has not received any financial support.Keywords : low-dose oral food challenge, peanut, food allergy, low-dose-tolerant, tolerant, pediatric, anaphylaxisTo the Editor,Peanuts cause severe allergic reactions, and only 20% of peanut-allergic patients acquire tolerance.1 Peanut oral food challenge (OFC) has a high risk of severe symptoms such as anaphylaxis, and OFC is avoided in children with an immediate history, especially with a history of anaphylaxis.1Peanut-allergic patients and their guardians have a lower quality of life because of worry that anaphylaxis may occur at any time.2 Low-dose OFC may be useful to manage children with a history of anaphylaxis,3 but it has not been used to evaluate prognosis. This study investigated long-term prognosis after low-dose peanut OFC for patients with a history of immediate reactions, including anaphylaxis.We retrospectively analyzed participants with a history of immediate symptoms due to peanut ingestion, who received baseline low-dose OFC with 133 mg of peanut protein from August 2013–August 2017 at Sagamihara National Hospital (Figure 1), and evaluated two-year tolerance acquisition.We defined tolerance as passing an OFC with 795 mg protein (medium-dose OFC) and ingesting more than 795 mg protein without symptoms at home; consuming this dose enables cessation of strict avoidance in daily life. We defined baseline low-dose OFC negative patients as the low-dose-tolerant group and positive patients as the low-dose-reactive group. The low-dose-tolerant group was instructed to consume 133 mg at home twice a week. Then, based on guardians’ preference, patients received a medium-dose OFC every 6 months or gradually increased peanut ingestion to 795 mg at home under a physician’s direction. The low-dose-reactive group completely avoided peanuts and received low-dose OFC every 6 months. When the low-dose-reactive group passed low-dose OFC, they received medium-dose OFC (Supplementary Figure 1).Anaphylaxis was defined according to the World Allergy Organization Guidelines.4 OFC protocol is described in the supplementary information.5 The percentage of patients who acquired tolerance within two years was estimated using Kaplan-Meier curves. The co-factors for tolerance acquisition were analyzed using Cox regression analysis. Multivariate analysis was performed on the results of low-dose OFC, total IgE, peanut-specific IgE (Pn-sIgE), and history of peanut-related anaphylaxis. SPSS (version 27.0; SPSS Inc., Chicago, IL) was used for all analyses; p <0.05 was considered statistically significant. The Ethics Committee of The Sagamihara National Hospital (2016-015) approved the study according to the Helsinki Declaration. Written informed consent was obtained from all patients’ guardians.Fifty-three patients (median age, 7.1 years) were enrolled; 43% had a history of anaphylaxis. The median Pn-sIgE level was 20.7 (interquartile range 7.0–57.5) kUA/L. The median Ara h 2-specific IgE level was 10.4 (4.98–28.3) kUA/L. The median thresholds of past immediate symptoms were 26.6 mg (13.3–133) (Supplementary Table 1).Twenty-one patients (40%) passed the low-dose OFC and were defined as the low-dose-tolerant group, and 32 (60%) failed and were defined as the low-dose-reactive group (Supplementary Table 1); 35% of patients with a history of anaphylaxis passed the low-dose OFC. During low-dose OFC, oral mucosal symptoms were most common (72%), then gastrointestinal (63%) and respiratory symptoms (63%). Three patients required intramuscular adrenaline (Supplementary Table 2). When the low-dose-tolerant patients ingested low-dose peanuts at home, six (29%) had mild reactions like oral and throat discomfort; most reactions resolved naturally and did not require medical attention.In the low-dose-tolerant group, 13 patients (62%) acquired tolerance within 2 years, including five patients with a history of anaphylaxis, whereas in the low-dose-reactive group, one patient (3%), with no history of anaphylaxis, acquired tolerance (p <0.001) (Figure 2). In the low-dose-reactive group, 6% of patients passed low-dose OFC within two years.The predictive factors of failure to acquire tolerance have been positive reactions to low-dose OFC (crude hazard ratios of total IgE, Pn-sIgE: 0.37 [95% confidence interval 0.15–0.94, p =0.04), and log (Pn-sIgE) 2.23 [1.01–4.92], p =0.048) (Supplementary Table 3). In 23 patients with a history of anaphylaxis, five (22%) acquired tolerance. In 30 patients with no history of anaphylaxis, nine (30%) acquired tolerance. History of anaphylaxis did not significantly affect tolerance acquisition (Supplementary Figure 2).This is the first report showing that low-dose OFC can be undergone relatively safely with tolerance acquisition in some peanut-allergic patients, including patients with a history of anaphylaxis. Patients with a history of anaphylaxis have a lower quality of life because of worry that anaphylaxis may occur at any time.6 Therefore, these results are significant because if patients realize that low-dose peanuts can be ingested, complete avoidance becomes unnecessary, and tolerance acquisition could be assessed. The low-dose-reactive group was less likely to develop tolerance and required careful follow-up to prevent accidental ingestion.Previous studies of long-term prognosis after peanut OFC excluded patients with a history of anaphylaxis,1 therefore, their tolerance acquisition based on the results of OFC was unknown. In our current study, more than half of patients in low-dose-tolerant groups acquired tolerance within two years, even those with a history of anaphylaxis. Furthermore, one-fifth of patients with a history of anaphylaxis tolerated peanuts, and there was no significant difference between patients with and without a history of anaphylaxis in acquiring tolerance. Therefore, passing low-dose OFC could be considered to assess tolerance acquisition, regardless of the history of anaphylaxis.It has been reported that peanut OFC is high risk because it often causes anaphylaxis and other serious symptoms.1 In the previous studies of peanut OFC, subjects have no history of anaphylaxis or as few as 10%, while this study had 40%, but the occurrence of anaphylaxis in OFC was comparable.1,7 Furthermore, there is a report of a group of subjects, 83% of whom had a history of anaphylaxis, and all patients reacted with anaphylaxis in OFC.8 It has been reported that the incidence of anaphylaxis with OFC was higher with progression up to the total OFC ingested.7 Therefore this study suggests that low-dose OFC is relatively safe in patients with a history of anaphylaxis.Recently, some trials of low-dose oral immunotherapy showed that ingesting low-dose peanuts (133-300 mg) could induce immunological changes and allow the intake of larger amounts.9Similarly, daily ingestion of low-dose wheat is effective in increasing consumption dose and preventing accidental symptoms, even in patients with a history of anaphylaxis.10 Therefore, twice weekly ingestion of 133 mg in the low-dose-tolerant group may yield oral tolerance. In addition, few serious reactions were observed in the low-dose-tolerant group during the subsequent at-home dose escalation in this study.This study has several limitations. First, 33 subjects were excluded because their two-year course could not be tracked. Although the excluded and included patients’ backgrounds were similar (Supplementary Table 4), predictors of tolerance acquisition, such as anaphylaxis may be different with more subjects. Second, there was a lack of information on several points. Although at-home intake methods were unified, the frequency of home peanut intake and adherence was unknown. Additionally, we couldn’t confirm thresholds of past immediate symptoms in 25% of subjects. However, the median thresholds were 26.6 mg in 75% of subjects who were able to assess the threshold. Therefore, we assume that thresholds in the remaining children were similar.For peanut-allergic patients with a history of anaphylaxis, low-dose OFC is relatively safe and effective in the assessment of tolerance acquisition. Low-dose OFC results may effectively stratify peanut-allergic patients with anaphylaxis history with good and poor tolerance acquisition to select optimal management plans.Nobuko Akamatsu, MD, PhD1,2, Ken-ichi Nagakura, MD, PhD1, Sakura Sato, MD3, Noriyuki Yanagida, MD, PhD1,3, Motohiro Ebisawa, MD, PhD3,1Department of Pediatrics, National Hospital Organization, Sagamihara National Hospital, Kanagawa, Japan2Department of Pediatrics and Adolescent Medicine, Tokyo Medical University Hospital, Tokyo, Japan3Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan
Dupilumab therapy in children aged 6 months to 12 years with uncontrolled moderate-to...
Jie Li
Bingjing Zhou

Jie Li

and 5 more

March 31, 2023
Article type: Research LetterTitle: Dupilumab therapy in children aged 6 months to 12 years with uncontrolled moderate-to-severe atopic dermatitis: a Chinese real-world study
Examine the advantages of an integrated scalability approach at various cloud stack l...
Ahmed Alobaidi
SeyedEbrahim Dashti

Ahmed Alobaidi

and 1 more

March 31, 2023
The development of cloud computing has significantly altered how services are built, deployed, and made accessible to users outside of the organization. In actuality, the pay-as-you-go model of dispersed IT supported by the cloud computing paradigm calls for the outsourcing of software services and applications. In this situation, the capacity to ensure effective cloud performance management and to facilitate automated scalability become fundamental prerequisites. Users of the cloud are becoming more and more interested in a transparent and coherent image of the cloud, where performance is guaranteed in a variety of situations and under a variety of loads. In this essay, We examine the advantages of an integrated scalability approach at various cloud stack layers, concentrating on the database and compute infrastructure layers. In order to achieve this, we offer various performance measurements and a set of rules based on them to assess the cloud stack’s condition and scale it as needed to maintain stable performance. Then, using a proof-of-concept architecture, we empirically investigate three scaling scenarios for cloud performance: database only, computing infrastructure solely, and the scenario where computing infrastructure and database compete for resources.
Benchmarking criteria for a cloud data warehouse
Ahmed Alobaidi
SeyedEbrahim Dashti

Ahmed Alobaidi

and 1 more

March 31, 2023
The Terasort benchmark and the YCSB benchmark are the two most used cloud computing benchmarks. Despite the fact that these benchmarks are quite helpful, data warehouse systems and associated OLAP technologies were not the focus of their creation. We initially introduce cloud computing and data warehouse systems in this essay. Then, we contend that the TPC-H benchmark, which is the most well- known benchmark for decision support systems, conflicts with the justifications for cloud computing (scalability, elasticity, pay-per-use, fault-tolerance characteristics), and customer relationship management (end- user satisfaction, Quality of Service features). Finally, we propose updated specifications for a benchmark for cloud data warehouse systems. The suggested specifications ought to make it possible to fairly compare the products offered by various cloud system providers .
Demand Response systems distributed on the cloud, offering a security & privacy f...
Ahmed Alobaidi
SeyedEbrahim Dashti

Ahmed Alobaidi

and 2 more

March 31, 2023
Demand Response (DR) is quickly becoming a critical component of the contemporary energy industry, notably in EU energy markets. As a result, substantial work has gone into standardizing demand response data models. As a result, an increasing number of demand response concepts are based on these standards. As a result, an increasing number of demand response concepts are based on these standards. These approaches, however, are often centralized, and those that rely on cloud solutions employ the cloud as a centralized data repository, assuming that the data is already homogenised when saved, i.e. all data has the same structure and type. In practice, however, DR plans rely on a number of components that deliver data in a variety of forms and types. Furthermore, the various DR standards establish models for various data formats, which impede data sharing between different DR systems. This article introduces CIM, a generic technology that allows current disaster recovery systems to disperse their components in the cloud while providing a robust security and privacy foundation for data interaction. Furthermore, the CIM includes a semantic interoperability layer capable of transforming data into a normalised form when transferred, allowing it to be consumed transparently by DR components. Experiments support the CIM as a solution for DR systems to decentralize their designs and share heterogeneous data with other DR systems that adhere to other DR standards.
Highly Stable Strontium Fluoride as a Thickness Tolerant Electron‐Selective Contact f...
Wenxian Wang
Lun Cai

Wenxian Wang

and 8 more

March 31, 2023
Commercialized passivated emitter rear cell (PERC) silicon solar cells feature direct contact of metal with silicon, which leads to severe recombination loss and low open circuit voltage (Voc). To overcome the loss, the authors demonstrate a highly stable and thickness-tolerant dopant-free electron-selective contact consisting of a strontium fluoride/aluminium (SrF2/Al) stack. The inserting SrF2 layer can mitigate the Fermi-level pinning effect between the silicon substrate and the Al electrode. Besides, a relatively low Ohmic contact resistivity of 2 mΩ·cm2 on lightly doped n-type c-Si can be achieved when using 4 nm of SrF2. Moreover, the formed contact within 9 nm SrF2 is stable for over 5000 hours in the air without encapsulation. Solar cells with this novel dopant-free electron-selective contact reach a power conversion efficiency (PCE) of 21.56%. The promising results and its stable nature, indicate its potential to act as efficient electron-selective contact for various optoelectronic devices.
Energy-efficient switching method using input-swapping for high resolution SAR ADCs
Serhat Kocak
Tayfun AKIN

Serhat Kocak

and 1 more

March 31, 2023
This paper presents an energy-efficient digital-to-analog converter (DAC) switching method with low common-mode variations for high resolution successive approximation register (SAR) analog-to-digital converters (ADCs), while enabling to implement resolutions such as 14-bit as compared to the typical 10-bit. The proposed switching method enables high resolution by having a nearly constant common-mode voltage and employing input-swapping to use the reference voltage (Vref) only in the sampling phase. This method eliminates the need for the third reference voltage during the entire DAC switching steps, which reduces the required number of switches even compared to the state-of-the-art methods that use low number of switches. The use of lower number of switches not only lowers the DAC control logic complexity, but also results in a faster operation, lower power, and smaller area. When compared to conventional 10-bit SAR ADCs, the proposed switching method in a 10-bit implementation reduces the average switching energy and area by 93.7 % and 75 %, respectively, while offering high resolution implementation options such as 14 bits.
Evolution of Grounding Failure-Insulation Failure of 10 kV Cable Joints: Prerequisite...
Yifeng  Zhao
Gang  Liu

Yifeng Zhao

and 5 more

March 31, 2023
An explosion accident in an enclosed cable trench caused by the discharge of 10 kV three-phase cable joints is discussed. Combined with the disassembly analysis, the fault recording data analysis, and the validation of experiment, the evolution of the cable joint fault is deduced and discussed. The results show that the trigger of the cable joint fault is the creepage discharge at the XLPE-SiR insulation interface. This results in the partial breakdown and the grounding failure of three-phase cable joints. Under the long-term floating potential and current thermal effect, the insulations are gradually ablated and decomposed into a large amount of combustible gas. Finally, the accumulated combustible gas is ignited by the arc caused by a three-phase short circuit at the moment of the reclosing operation. The analytical method and conclusions proposed in this paper can provide suggestions and guidance for the analysis of similar fault accidents in the future.
Complex regional pain syndrome of the knee after COVID-19 Vaccine in an adult patient
Faten Frikha
Yosr Hentati

Faten Frikha

and 6 more

March 30, 2023
Title: Complex regional pain syndrome of the knee after COVID-19 Vaccine in an adult patient
Attenuation of the contribution of groundwater to a wetland caused by groundwater ove...
Tianyu Zhou
Longcang Shu

Tianyu Zhou

and 3 more

March 30, 2023
The continuous exploitation of groundwater has made wetland degradation an ecological and geological environmental problem that cannot be ignored and which has had impacts on the ecological environment and human production and life. In this study, with the help of Visual MODFLOW software, we used numerical simulation technology to simulate the wetland–aquifer interaction during the multiyear pumping process, establish a quasi-ideal model of wetlands based on the actual area of the Baiyangdian Basin, simulate the relationship of water quantity change between wetlands and piedmont plain aquifers during groundwater exploitation and its natural recovery process, and quantify the attenuation of the contribution of groundwater to wetlands caused by groundwater overexploitation. The results show that the impact of groundwater overexploitation on wetland degradation is mainly divided into two parts: one is the reduced base flow from the piedmont plain to the wetland, and the other is the induced infiltration caused by the reverse recharge of groundwater from the wetland due to the pumping effect. At the beginning of pumping, the effect of reduced base flow on wetland degradation is dominant, but with a longer pumping time, the effect of induced infiltration on wetland degradation exceeds the effect of reduced base flow. After stopping pumping, the effect of induced infiltration on wetland degradation responds instantly and decreases rapidly, while the effect of reduced base flow on wetland degradation continues for a long time. The total water reduction of wetlands increases with increasing hydraulic conductivity, and in actual wetland areas, if groundwater overexploitation is not restricted or artificial supply measures are not taken, the amount of wetland water will gradually decrease until it is exhausted.
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