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Visible-Light-Induced Domino Cyclization to Access Pyri-do[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction
  • +4
  • Wanqing Zuo,
  • Yu Cheng,
  • Zhizhen Zhu,
  • Lingling Zuo,
  • Xiao Geng,
  • Zhifang Li,
  • Lei Wang
Wanqing Zuo
Hangzhou Normal University
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Yu Cheng
Taizhou University
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Zhizhen Zhu
Taizhou University
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Lingling Zuo
Taizhou University
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Xiao Geng
Taizhou University
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Zhifang Li
Hangzhou Normal University
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Lei Wang
Taizhou University

Corresponding Author:[email protected]

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Abstract

Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now reported a radical-polar crossover (RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced dom-ino cyclization. The reaction exhibited a broad substrate scope (> 40 examples) including complex molecules, which highlighted the utility of this strategy for the construction of a library of bioactive analogs.
23 Mar 2024Submitted to Chinese Journal of Chemistry
12 Apr 2024Editorial Decision: Revise Minor
08 May 2024Submission Checks Completed
08 May 2024Assigned to Editor
08 May 2024Review(s) Completed, Editorial Evaluation Pending
08 May 2024Editorial Decision: Accept