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A survey assesing the impact of COVID-19 and elexacaftor/tezacaftor/ifavacaftor on both physical and mental health in persons with cystic fibrosis
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  • Colleen Sakon,
  • Hilary Vogt,
  • cynthia brown,
  • Emma Tillman
Colleen Sakon
Indiana University Health Inc

Corresponding Author:[email protected]

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Hilary Vogt
Indiana University Health Inc
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cynthia brown
Indiana University School of Medicine
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Emma Tillman
Indiana University School of Medicine
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Abstract

While our survey showed that PwCF felt that the COVID-19 pandemic had impacted their mental health more than ETI therapy, around 9% of survey responders felt that ETI did cause an increase in either anxiety or depression. This finding was similar to the numbers Spoletini and colleagues found in their adult clinic. They also found that a dose reduction of ETI improved or resolved mental health adverse events for most patients. [2] A recently published study by Guimbellot and colleagues studied ivacaftor levels in PwCF who were on ivacaftor monotherapy and showed many patients had levels higher than the published minimum effective concentrations.[6] Thus, there may be a correlation between ETI levels and mental health adverse events that should be further explored in a prospective manner.
22 Aug 2022Submitted to Pediatric Pulmonology
22 Aug 2022Submission Checks Completed
22 Aug 2022Assigned to Editor
23 Aug 2022Reviewer(s) Assigned
11 Sep 2022Review(s) Completed, Editorial Evaluation Pending
26 Sep 2022Editorial Decision: Revise Minor
13 Oct 20221st Revision Received
20 Oct 2022Submission Checks Completed
20 Oct 2022Assigned to Editor
20 Oct 2022Review(s) Completed, Editorial Evaluation Pending
20 Oct 2022Reviewer(s) Assigned
07 Nov 2022Editorial Decision: Revise Minor
10 Nov 20222nd Revision Received
10 Nov 2022Assigned to Editor
10 Nov 2022Review(s) Completed, Editorial Evaluation Pending
10 Nov 2022Submission Checks Completed
10 Nov 2022Reviewer(s) Assigned
25 Nov 2022Editorial Decision: Accept