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Clinical and Epidemiological Features and Severity Markers in Children Admitted with Multisystem Inflammatory Syndrome in Children (MISC) in a Tertiary Care Center in UAE
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  • Habiba H. AboAlEla,
  • Abdulrahman Ali,
  • Ghadah Al-Sharif A,
  • Walid Abuhammour,
  • Mohammad Almoosa,
  • Diego Arango,
  • Ali Al-Fraihat,
  • Samuel Ho,
  • Amar HK,
  • Rizwana Popatia,
  • Lemis Yavuz
Habiba H. AboAlEla
Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine

Corresponding Author:[email protected]

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Abdulrahman Ali
Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine
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Ghadah Al-Sharif A
Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine
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Walid Abuhammour
Al Jalila Children's Specialty Hospital
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Mohammad Almoosa
Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine
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Diego Arango
Al Jalila Children's Specialty Hospital
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Ali Al-Fraihat
Al Jalila Children's Specialty Hospital
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Samuel Ho
Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine
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Amar HK
Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine
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Rizwana Popatia
Mohammed Bin Rashid University of Medicine and Health Sciences College of Medicine
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Lemis Yavuz
Al Jalila Children's Specialty Hospital
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Abstract

Background: Multisystem Inflammatory Syndrome in Children (MISC) is a phenomenon that appeared in children infected with or exposed to SARS-CoV-2. The typical onset of MISC is 4-6 weeks following SARS-CoV-2 infection and is formulated to be due to an immune response. Methods: Our study retrospectively analyzed data from a tertiary center in UAE of MISC patients who were admitted to either general pediatric wards or pediatric intensive care (PICU) or who came exclusively for follow-up (post PICU admission) from May 2020 to August 2021.   Results: The total sample size is 50 patients and the study included a comparison of PICU admissions with none PICU admissions. The PICU sample size was 18 patients, 50% females, with mean age of 8.3 years all were previously healthy. PICU patients had deranged blood counts with a lower hemoglobin count, a more pronounced lymphopenia and thrombocytopenia along with hypoalbuminemia. PICU patients presented with relatively higher inflammatory markers: CRP, PCT, ferritin and D-dimer. Immunological studies were significantly higher for IL-6 levels in PICU patients. On echocardiography, higher myocardial dysfunction was more notable in patients admitted to PICU. Children admitted in PICU were provided with more extensive therapy. As part of our study course, we re-evaluated our PICU patients twice, once at 48 hours post PICU admission and again 4-6 weeks after discharge from the hospital. No deaths have been recorded in the cohort. Conclusion: This study evaluated risk factors of MISC and potential severity features. Follow up of patients on discharge showed improvement across all domains.
16 May 2022Submitted to Pediatric Pulmonology
16 May 2022Submission Checks Completed
16 May 2022Assigned to Editor
16 May 2022Reviewer(s) Assigned
21 Aug 2022Review(s) Completed, Editorial Evaluation Pending
29 Aug 2022Editorial Decision: Revise Major
26 Nov 20221st Revision Received
09 Dec 2022Submission Checks Completed
09 Dec 2022Assigned to Editor
09 Dec 2022Review(s) Completed, Editorial Evaluation Pending
09 Dec 2022Reviewer(s) Assigned
28 Mar 2023Editorial Decision: Revise Minor
11 May 20232nd Revision Received
11 May 2023Submission Checks Completed
11 May 2023Review(s) Completed, Editorial Evaluation Pending
11 May 2023Assigned to Editor
11 May 2023Reviewer(s) Assigned
10 Jun 2023Editorial Decision: Revise Minor
06 Jul 20233rd Revision Received
07 Jul 2023Submission Checks Completed
07 Jul 2023Assigned to Editor
07 Jul 2023Review(s) Completed, Editorial Evaluation Pending
09 Jul 2023Editorial Decision: Revise Minor
11 Jul 20234th Revision Received
13 Jul 2023Submission Checks Completed
13 Jul 2023Assigned to Editor
13 Jul 2023Review(s) Completed, Editorial Evaluation Pending
15 Jul 2023Editorial Decision: Accept