Factors predicting the final diagnosis of peripheral blood
hypereosinophilia-- a retrospective analysis
Abstract
To the Editor, Blood hypereosinophilia (HE), defined as eosinophils in
peripheral blood over 1.5 G/L, is clinical challenge in modern medicine
[1]. A variety of causes and symptoms make patients undergo many
tests before final diagnosis is made and the necessary therapy is
initiated [1]. Factors predicting the final diagnosis might prove
useful, as some of the more costly and invasive tests could be skipped
[1]. The aim of the study was to find prognostic factors which may
identify the cause of HE. Medical records of 39 patients with observed
blood HE detected in at least one test who visited the Department of
Allergology in Gdansk in the years 2010–2022 were analysed. In general,
we supplemented the standard tests with additional ones when predicting
neoplastic or autoimmune diseases. The peripheral blood morphology,
serum biochemistry, parasitological examination, immunological studies
(antineutrophil cytoplasmic antibodies (ANCA) test), additional tests,
including the aspirin provocation test (performed in 46% of patients
(n=18)), spirometry, histopathology and cytology of the bone marrow
(done in 56% of patients (n=22)) were performed. The statistical
analysis was conducted using binary logistic regression performed using
Statistica 13 software.