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Non-canonical Endoplasmic Reticulum Stress Transducers CREB3 family in cancer and other diseases
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  • Yaqi Han,
  • Ziwei Li,
  • Zijian Cao,
  • Jirui Sun,
  • Jinku Zhang
Yaqi Han
Hebei Medical University
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Ziwei Li
Chengde Medical University
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Zijian Cao
Institute of Translational Medicine
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Jirui Sun
Baoding No 1 Central Hospital
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Jinku Zhang
Baoding No 1 Central Hospital

Corresponding Author:[email protected]

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Abstract

Background When unfolded proteins accumulate in the endoplasmic reticulum (ER), they cause ER stress and activate the pathways of unfolded protein response (UPR), constituted by a set of canonical ER stress transducing proteins. While the classical UPR is well-studied, the functions of non-canonical ER stress transducers are emerging. Findings The CREB3 (cyclic AMP responsive element binding protein 3) family, which contains five members including CREB3, CREB3L1, CREB3L2, CREB3L3, and CREB3L4, is the most important non-canonical ER stress response factor sensing and modulating unfolded protein homeostasis. As novel ER stress transducers, the CREB3 family plays important roles in regulating protein folding, modification, and secretion, contributing to biological events, including cell proliferation, differentiation, and migration in diverse contexts, especially in cancer. Conclusion This review summarized the roles of the CREB3 family in development and disease progression, with an aim to provide references for further research and clinical translation.
23 Sep 2023Submitted to Cancer Reports
29 Sep 2023Submission Checks Completed
29 Sep 2023Assigned to Editor
29 Sep 2023Review(s) Completed, Editorial Evaluation Pending
06 Oct 2023Reviewer(s) Assigned