The construct of wellbeing has been criticised for being a neoliberal construction of western individualism that ignores wider systemic issues including increasing burden of chronic disease, worsening inequality, concerns over environmental degradation and climate change. While these criticisms are somewhat disingenuous, there is a need for biopsychosocial models to extend theoretical grounding beyond individual wellbeing, and incorporate overlapping contextual issues relating to community and environment, the domain of social ecological theory. Our first GENIAL model (Kemp, Arias & Fisher, 2017) provided a more expansive view of pathways to longevity or mortality in the context of the individual health and wellbeing, emphasising bidirectional links to positive social ties and the impact of sociocultural factors. In this paper, we build on these ideas and propose GENIAL 2.0, focusing on intersecting individual-community-environmental contributions to health and wellbeing, and laying an evidence-based, theoretical framework on which future research and innovative therapeutic innovations could be based. We suggest that our transdisciplinary model of wellbeing – focusing on individual, community and environmental contributions to personal wellbeing – will help to move the research field forward. In reconceptualising wellbeing, GENIAL 2.0 bridges the gap between psychological science and public health, and also presents opportunities for enhancing the health and wellbeing of people living with chronic conditions with implications for future generations including the very survival of our species.