Consequently, an important consideration is also the typical trade-off in computational chemistry between thermochemical accuracy and computational time. Since traditional MP2 and coupled-cluster methods exhibit high computational complexity, much research ignored them for medium to large organic molecules due to the time required. Particularly in computational screening and conformer generation, fast molecular force fields such as MMFF94 and UFF, as well as semiempirical quantum chemical methods such as AM1,\cite{Dewar_1985} PM3,\cite{Stewart_1989} PM6,\cite{Stewart_2007} and PM7\cite{Stewart_2012} were considered "good enough" to generate structures for further refinement with density functional and other methods. More recent methods, particularly the ANI machine learning methods and the GFN family of density functional tight binding appear to significantly improve on accuracy with only modest increases in the time required.