Figure Legends
Figure 1 Schematic representation of the two-sample mendelian randomization analysis.
Assumption 1 represents that genetic instrumental variables (IVs) are strongly associated with exposure and only affected the outcome through the exposure; assumption 2 represents that IVs are not associated with confounders; assumption 3 represents that IVs are not directly associated with the outcome.
Figure 2 Forest plot of the association between genetically predicted telomere length and the percentage of immune cells.
OR means a change in outcome risk associated with a 1-standard deviation decrease in genetically determined telomere length. OR, odds ratio; CI, confidence interval; IVW, inverse variance weighted.
Figure 3 Scatter plots showing the causal effect of SNPs on telomere length against the effects on the quantity of immune cells.
SNP, single nucleotide polymorphisms; MR, Mendelian randomization. (A-I) T cell % lymphocyte, Natural Killer T %T cell, CD8+ Natural Killer T %T cell, CD4 regulatory T cell % CD4+ T cell, Activated CD4 regulatory T cell %CD4+ T cell, Effector Memory CD8+ T cell %CD8+ T cell,Transitional B cell %B cell, Naive-mature B cell %B cell, Memory B cell %B cell.