5. Conclusions and Prospects
In summary, MPTT is a new type of treatment that converts light into
mild heat for therapeutic effects. Compared with traditional radiation
therapy and chemical drugs, MPTT has attracted much attention in the
medical field because of its advantages such as less trauma, fewer side
effects, and precise positioning. MPTT uses NIR light absorption
capacity of nanomaterials and the local thermal effect generated after
absorption for treatment. Through the selective aggregation of
nanomaterials in tumor tissue, combined with the appropriate wavelength
of light irradiation, the nanomaterials will produce photothermal
effect, so as to increase the local temperature of lesion tissue, so as
to achieve the purpose of treatment. In MPTT, PTAs are the core to
achieve the photothermal effect. Common nanomaterials include Au NPs,
graphene, carbon nanotubes have good optical properties and
biocompatibility, have high PCE and exist stably in vivo. By adjusting
the properties of nanomaterials and the parameters of light exposure,
selective destruction of tumor tissue can be achieved while maximizing
protection of surrounding normal tissue. In addition, MPTT can also be
combined with other treatments, such as chemical drugs, radiation
therapy, etc., to achieve a synergistic therapeutic effect. So far, some
early clinical trials have shown that MPTT has good safety and efficacy
in tumor treatment. With the continuous development of nanomaterials
technology and the promotion of clinical applications, MPTT is expected
to become one of the important means of cancer treatment in the future.
However, MPTT is still in its infancy and further basic research and
clinical validation are still needed. There is still a need to
strengthen the in-depth study of its mechanism, optimize treatment
options, and address related safety and biological issues. As an
innovative therapeutic method, MPTT has great potential and application
prospect. However, we still need to be cautious and continue to conduct
further studies to ensure its safety and efficacy. With the continuous
development of technology and the advancement of clinical practice, it
is believed that MPTT will bring better treatment results for cancer
patients and improve their quality of life.