Background
Schizophrenia is a severe mental disorder with heavy burden of comorbidity (1), which make difficulties in the clinical treatment and management of schizophrenia and its comorbidities. The most common therapy for schizophrenia is antipsychotics (APs), most of which are metabolized by the cytochrome P450 (CYP450) system in the liver. Previously, studies had reported that some people can tolerate overdose of APs and this may be explained by pharmacogenetic mechanisms (2). It was found that CYP2D6 ultra-rapid metabolizers were associated with lower risperidone-related adverse events than poor/intermediate metabolizers (3). Therefore, genetic profiling in drug metabolism may help guide clinical treatment in psychiatric diseases (4).
In this case, we described a female patient with schizophrenia who took several kinds of drugs in overdose daily for 2 years, but only slight side effects were observed. This condition attracts our attention and provides some inspiration and reference for the clinical treatment of mental disorders.