Abstract
Background
Liver cytochrome P450 (CYP450) enzymes play an important role in
metabolizing antipsychotics (APs) and other drugs. Excessive use of
drugs can impair liver function and even other organs, thus causing
several adverse effects. In addition, metabolizer types of CYP450
enzymes may influence the therapeutic effects and drug reactions. In
this case report, we introduce a 52-year-old female with a 23-year
history of schizophrenia who took overdose of multiple kinds of APs and
other herbal preparations together for nearly two years, and she
presented with poor treatment effects and minor side effects of APs.
This case adds clinical examples for those patients with poor efficacy
and alarming drug tolerance.