Background
Schizophrenia is a severe mental disorder with heavy burden of
comorbidity (1), which make difficulties in the clinical treatment and
management of schizophrenia and its comorbidities. The most common
therapy for schizophrenia is antipsychotics (APs), most of which are
metabolized by the cytochrome P450 (CYP450) system in the liver.
Previously, studies had reported that some people can tolerate overdose
of APs and this may be explained by pharmacogenetic mechanisms (2). It
was found that CYP2D6 ultra-rapid metabolizers were associated with
lower risperidone-related adverse events than poor/intermediate
metabolizers (3). Therefore, genetic profiling in drug metabolism may
help guide clinical treatment in psychiatric diseases (4).
In this case, we described a female patient with schizophrenia who took
several kinds of drugs in overdose daily for 2 years, but only slight
side effects were observed. This condition attracts our attention and
provides some inspiration and reference for the clinical treatment of
mental disorders.