Derived asthma phenotypes by disease prognosis and severity
Cluster 1 had the highest proportion of individuals with uncontrolled asthma based on GINA classification and the highest proportion of individuals on GINA treatment steps 4 and 5. Cluster 1 also had the second-highest proportion of individuals who only used short-acting beta-agonists (SABA) or never had used asthma medication. On the other hand, cluster 4 had the lowest proportion of individuals with uncontrolled asthma, the lowest proportion of individuals on GINA treatment steps 4 and 5, and the highest proportion of individuals who only used short-acting beta-agonists (SABA) or never had been prescribed asthma medication. Clusters 2 and 3 were in-between clusters 1 and 4 in regarding asthma severity (Figure 1: B ).