Variables included in deriving the phenotypes
We included a list of 47 variables, which were selected based on clinical experience and previous studies. This comprehensive list of variables was included to capture a full representation of the clinical presentation, pathophysiological mechanisms, and potential risk factors related to asthma. The variables were grouped as follows: (1) demographics/triggers/risk factors; (2) symptom profiles; (3) measures of pulmonary function; (4) disease prognosis and severity indicators; and (5) measures of inflammation. All variables were self -reported by participants except for lung function, reversibility, measures of lung diffusion capacity, and inflammation biomarkers which were measured objectively in the clinic. A detailed list of all variables is presented in the Supplementary file .

Statistical analysis