Study selection

We included studies if they fulfilled the following criteria: Patients with a confirmed diagnosis of COVID‐19
Intervention: Infliximab
Control: placebo, standard of care (SOC), any treatment
Efficacy outcomes of interest: mortality rate, need for mechanical ventilation, and ICU admission
Safety outcomes of interest: the incidence of any adverse events (AEs)
The studies which conducted on animal models, case reports, case series, and letters to the editor were excluded.