Variable Univariate analysis Univariate analysis Univariate analysis Univariate analysis Univariate analysis Multivariate analysis Multivariate analysis Multivariate analysis Multivariate analysis Multivariate analysis Multivariate analysis
EFS EFS OS OS EFS EFS OS OS
HR (95%CI) HR (95%CI) p Value p Value HR (95%CI) p Value p Value HR (95%CI) p Value p Value HR (95%CI) p Value p Value
Age ≤2 years 1.226 (0.943-1.594) 1.226 (0.943-1.594) 0.1284 0.1284 1.086 (0.786-1.502) 0.6162 0.6162 0.774 (0.578-1.038) 0.0869 0.0869 0.729 (0.509-1.043) 0.0840 0.0840
WBC ≥100´109/L 1.501 (1.189-1.895) 1.501 (1.189-1.895) 0.0006 0.0006 1.208 (0.902-1.618) 0.2056 0.2056 1.655 (1.295-2.117) 0.0001 0.0001 1.348 (0.994-1.828) 0.0549 0.0549
Normal karyotype 1.085 (0.853-1.380) 1.085 (0.853-1.380) 0.5050 0.5050 1.082 (0.808-1.450) 0.5962 0.5962
Complex karyotype 1.093 (0.834-1.432) 1.093 (0.834-1.432) 0.5186 0.5186 1.290 (0.937-1.774) 0.1180 0.1180
t(8;21) 0.437 (0.306-0.626) 0.437 (0.306-0.626) <0.0001 <0.0001 0.415 (0.260-0.663) 0.0002 0.0002 0.322 (0.201-0.516) <0.0001 <0.0001 0.258 (0.140-0.475) <0.0001 <0.0001
inv(16) 0.646 (0.461-0.904) 0.646 (0.461-0.904) 0.0109 0.0109 0.338 (0.197-0.580) 0.0001 0.0001 0.366 (0.251-0.535) <0.0001 <0.0001 0.203 (0.114-0.359) <0.0001 <0.0001
del5q/del7q/-5/-7 1.467 (0.984-2.187) 1.467 (0.984-2.187) 0.0599 0.0599 2.367 (1.552-3.610) 0.0001 0.0001 1.564 (1.029-2.377) 0.0364 0.0364 2.473 (1.574-3.884) 0.0001 0.0001
trisomy8/trisomy21 1.081 (0.793-1.473) 1.081 (0.793-1.473) 0.6217 0.6217 1.438 (1.016-2.033) 0.0401 0.0401 0.936 (0.683-1.282) 0.6788 0.6788 1.203 (0.846-1.710) 0.3046 0.3046
Minus X/Minus Y 0.443 (0.272-0.721) 0.443 (0.272-0.721) 0.0010 0.0010 0.522 (0.292-0.933) 0.0282 0.0282 0.845 (0.466-1.534) 0.5807 0.5807 1.142 (0.553-2.356) 0.7198 0.7198
CEBPA+ 0.638 (0.374-1.089) 0.638 (0.374-1.089) 0.0998 0.0998 0.481 (0.227-1.021) 0.0567 0.0567 0.398 (0.228-0.695) 0.0012 0.0012 0.313 (0.144-0.679) 0.0033 0.0033
FLT3_ITD-/NPM1+ 0.454 (0.242-0.851) 0.454 (0.242-0.851) 0.0138 0.0138 0.370 (0.153-0.898) 0.0279 0.0279 0.332 (0.172-0.639) 0.0010 0.0010 0.260 (0.105-0.645) 0.0037 0.0037
FLT3_ITD+ 1.544 (1.200-1.987) 1.544 (1.200-1.987) 0.0007 0.0007 1.485 (1.094-2.015) 0.0111 0.0111 1.330 (0.979-1.806) 0.0679 0.0679 1.099 (0.763-1.582) 0.6131 0.6131
WT1+ 2.114 (1.469-3.043) 2.114 (1.469-3.043) 0.0001 0.0001 1.942 (1.263-2.986) 0.0025 0.0025 2.013 (1.361-2.978) 0.0005 0.0005 1.853 (1.170-2.936) 0.0086 0.0086
KMT2A rearrangements 1.457 (1.136-1.868) 1.457 (1.136-1.868) 0.0030 0.0030 1.331 (0.981-1.806) 0.0660 0.0660 0.965 (0.721-1.291) 0.8099 0.8099 0.892 (0.629-1.265) 0.5218 0.5218
NUP98 fusions 1.538 (1.045-2.262) 1.538 (1.045-2.262) 0.0289 0.0289 1.398 (0.875-2.234) 0.1613 0.1613 1.147 (0.764-1.724) 0.5078 0.5078 0.842 (0.514-1.378) 0.4932 0.4932
SCT 0.620 (0.449-0.855) 0.620 (0.449-0.855) 0.0036 0.0036 0.934 (0.655-1.331) 0.7053 0.7053 0.348 (0.247-0.492) <0.0001 <0.0001 0.548 (0.377-0.797) 0.0017 0.0017
GO treatment 0.863 (0.701-1.061) 0.863 (0.701-1.061) 0.1618 0.1618 0.895 (0.695-1.153) 0.3914 0.3914 0.817 (0.663-1.006) 0.0574 0.0574 0.878 (0.680-1.133) 0.3160 0.3160
EMI at diagnosis 1.455 (1.128-1.877) 1.455 (1.128-1.877) 0.0039 0.0039 1.321 (0.967-1.804) 0.0802 0.0802 1.672 (1.283-2.179) 0.0001 0.0001 1.425 (1.033-1.964) 0.0307 0.0307