Variable |
|
Univariate analysis |
Univariate analysis |
Univariate analysis |
Univariate analysis |
Univariate analysis |
|
Multivariate analysis |
Multivariate analysis |
Multivariate analysis |
Multivariate analysis |
Multivariate analysis |
Multivariate analysis |
|
|
EFS |
EFS |
|
OS |
OS |
|
EFS |
EFS |
|
OS |
OS |
|
|
HR (95%CI) |
HR (95%CI) |
p Value |
p Value |
HR
(95%CI) |
p Value |
p Value |
HR (95%CI) |
p
Value |
p Value |
HR (95%CI) |
p Value |
p Value |
Age ≤2 years |
1.226 (0.943-1.594) |
1.226 (0.943-1.594) |
0.1284 |
0.1284 |
1.086 (0.786-1.502) |
0.6162 |
0.6162 |
0.774 (0.578-1.038) |
0.0869 |
0.0869 |
0.729 (0.509-1.043) |
0.0840 |
0.0840 |
WBC ≥100´109/L |
1.501 (1.189-1.895) |
1.501
(1.189-1.895) |
0.0006 |
0.0006 |
1.208 (0.902-1.618) |
0.2056 |
0.2056 |
1.655 (1.295-2.117) |
0.0001 |
0.0001 |
1.348 (0.994-1.828) |
0.0549 |
0.0549 |
Normal karyotype |
1.085 (0.853-1.380) |
1.085 (0.853-1.380) |
0.5050 |
0.5050 |
1.082 (0.808-1.450) |
0.5962 |
0.5962 |
|
|
|
|
|
|
Complex karyotype |
1.093 (0.834-1.432) |
1.093 (0.834-1.432) |
0.5186 |
0.5186 |
1.290 (0.937-1.774) |
0.1180 |
0.1180 |
|
|
|
|
|
|
t(8;21) |
0.437 (0.306-0.626) |
0.437 (0.306-0.626) |
<0.0001 |
<0.0001 |
0.415 (0.260-0.663) |
0.0002 |
0.0002 |
0.322
(0.201-0.516) |
<0.0001 |
<0.0001 |
0.258
(0.140-0.475) |
<0.0001 |
<0.0001 |
inv(16) |
0.646 (0.461-0.904) |
0.646 (0.461-0.904) |
0.0109 |
0.0109 |
0.338 (0.197-0.580) |
0.0001 |
0.0001 |
0.366 (0.251-0.535) |
<0.0001 |
<0.0001 |
0.203 (0.114-0.359) |
<0.0001 |
<0.0001 |
del5q/del7q/-5/-7 |
1.467 (0.984-2.187) |
1.467 (0.984-2.187) |
0.0599 |
0.0599 |
2.367 (1.552-3.610) |
0.0001 |
0.0001 |
1.564 (1.029-2.377) |
0.0364 |
0.0364 |
2.473 (1.574-3.884) |
0.0001 |
0.0001 |
trisomy8/trisomy21 |
1.081 (0.793-1.473) |
1.081 (0.793-1.473) |
0.6217 |
0.6217 |
1.438 (1.016-2.033) |
0.0401 |
0.0401 |
0.936 (0.683-1.282) |
0.6788 |
0.6788 |
1.203 (0.846-1.710) |
0.3046 |
0.3046 |
Minus X/Minus Y |
0.443 (0.272-0.721) |
0.443 (0.272-0.721) |
0.0010 |
0.0010 |
0.522 (0.292-0.933) |
0.0282 |
0.0282 |
0.845 (0.466-1.534) |
0.5807 |
0.5807 |
1.142 (0.553-2.356) |
0.7198 |
0.7198 |
CEBPA+ |
0.638 (0.374-1.089) |
0.638 (0.374-1.089) |
0.0998 |
0.0998 |
0.481 (0.227-1.021) |
0.0567 |
0.0567 |
0.398 (0.228-0.695) |
0.0012 |
0.0012 |
0.313 (0.144-0.679) |
0.0033 |
0.0033 |
FLT3_ITD-/NPM1+ |
0.454 (0.242-0.851) |
0.454 (0.242-0.851) |
0.0138 |
0.0138 |
0.370 (0.153-0.898) |
0.0279 |
0.0279 |
0.332 (0.172-0.639) |
0.0010 |
0.0010 |
0.260 (0.105-0.645) |
0.0037 |
0.0037 |
FLT3_ITD+ |
1.544 (1.200-1.987) |
1.544 (1.200-1.987) |
0.0007 |
0.0007 |
1.485 (1.094-2.015) |
0.0111 |
0.0111 |
1.330 (0.979-1.806) |
0.0679 |
0.0679 |
1.099 (0.763-1.582) |
0.6131 |
0.6131 |
WT1+ |
2.114 (1.469-3.043) |
2.114 (1.469-3.043) |
0.0001 |
0.0001 |
1.942 (1.263-2.986) |
0.0025 |
0.0025 |
2.013 (1.361-2.978) |
0.0005 |
0.0005 |
1.853 (1.170-2.936) |
0.0086 |
0.0086 |
KMT2A rearrangements |
1.457 (1.136-1.868) |
1.457 (1.136-1.868) |
0.0030 |
0.0030 |
1.331 (0.981-1.806) |
0.0660 |
0.0660 |
0.965
(0.721-1.291) |
0.8099 |
0.8099 |
0.892 (0.629-1.265) |
0.5218 |
0.5218 |
NUP98 fusions |
1.538 (1.045-2.262) |
1.538 (1.045-2.262) |
0.0289 |
0.0289 |
1.398 (0.875-2.234) |
0.1613 |
0.1613 |
1.147 (0.764-1.724) |
0.5078 |
0.5078 |
0.842 (0.514-1.378) |
0.4932 |
0.4932 |
SCT |
0.620 (0.449-0.855) |
0.620 (0.449-0.855) |
0.0036 |
0.0036 |
0.934 (0.655-1.331) |
0.7053 |
0.7053 |
0.348 (0.247-0.492) |
<0.0001 |
<0.0001 |
0.548 (0.377-0.797) |
0.0017 |
0.0017 |
GO treatment |
0.863 (0.701-1.061) |
0.863 (0.701-1.061) |
0.1618 |
0.1618 |
0.895 (0.695-1.153) |
0.3914 |
0.3914 |
0.817 (0.663-1.006) |
0.0574 |
0.0574 |
0.878 (0.680-1.133) |
0.3160 |
0.3160 |
EMI at diagnosis |
1.455 (1.128-1.877) |
1.455 (1.128-1.877) |
0.0039 |
0.0039 |
1.321 (0.967-1.804) |
0.0802 |
0.0802 |
1.672 (1.283-2.179) |
0.0001 |
0.0001 |
1.425 (1.033-1.964) |
0.0307 |
0.0307 |