3.1 Selection of Genetic Instruments
As previously mentioned, all SNPs used for genetic exposure prediction
met the rigorous criteria of a genome-wide significance level (p
< 1×10-5) and the requirement of an F-statistic >
10, indicating that all instruments were strong. We further excluded
SNPs associated with potential confounding factors using PhenoScannerV2.
Ultimately, 4 to 21 SNPs per herpes virus satisfied harmonization
criteria and were considered valid instruments.These SNPs data are
visible in theSupplemental
Table 2.