3.1 Selection of Genetic Instruments
As previously mentioned, all SNPs used for genetic exposure prediction met the rigorous criteria of a genome-wide significance level (p < 1×10-5) and the requirement of an F-statistic > 10, indicating that all instruments were strong. We further excluded SNPs associated with potential confounding factors using PhenoScannerV2. Ultimately, 4 to 21 SNPs per herpes virus satisfied harmonization criteria and were considered valid instruments.These SNPs data are visible in theSupplemental Table 2.