3.2 Causal Effects of HHV-6 on CLA
We explored the causal association between 14 SNPs for HHV-6 and CLA in individuals of European descent. The results from the IVW analysis indicated that HHV-6 significantly increased the risk of CLA (OR = 1.886, 95% CI = 1.053–3.378, p = 0.033). The MR-Egger method (OR = 1.503, 95% CI = 0.276–8.188; p = 0.646) and the weighted median (OR = 1.967, 95% CI = 0.894–4.325; p = 0.092) yielded consistent results, although they were not particularly significant. (Figure. 2). Moreover, we conducted a sensitivity analysis to verify the reliability of the IVW results. Sensitivity analyses confirmed the reliability of the IVW results, with tests for heterogeneity(IVW: Q = 12.508, p = 0.487; MR-Egger: Q = 12.426, p = 0.412) and horizontal pleiotropy(MR-Egger intercept = 0.032, p = 0.784) showing consistent results(Figure. 3 a).