3.3 Causal Effects of HSV on CLA
For HSV, we selected 4 SNPs for HSV-1,10 SNPs for HSV-2 and 19 SNPs for HSV infection and examined their effects on CLA. The results showed no significant association between HSV-1 (OR = 0.896, 95% CI = 0.141-5.691, p = 0.908), HSV-2 (OR = 1.075, 95% CI = 0.737-1.568, p = 0.706), and HSV infection (OR = 1.119, 95% CI = 0.826-1.515, p = 0.467) with CLA. The MR-Egger and weighted median also yielded similar results(all p > 0.05) (Figure. 2). Horizontal pleiotropy did not affect the MR analyses based on the MR-Egger regression intercept test, with intercept p-values of 0.998 for HSV-1, 0.954 for HSV-2, and 0.160 for HSV infection. The Cochran’s Q test results showed no heterogeneity for HSV-1 (p = 0.148) and HSV-2 (p = 0.250), but heterogeneity was detected for HSV infection (p = 0.040) (Figure. 3 b-d).