3.4 Causal Effects of VZV on CLA
Regarding VZV, we separately screened 8 SNPs for varicella and 16 SNPs for zoster virus. The IVW results did not support a causal effect of varicella or zoster virus (OR = 1.013, 95% CI = 0.803-1.277, p = 0.914; OR = 1.163, 95% CI = 0.762-1.777, p = 0.484) on CLA. The MR-Egger and weighted median methods also yielded p-values above 0.05(Figure. 2). Likewise, there was no horizontal pleiotropy for varicella (MR-Egger intercept = -0.047, p = 0.717) and the zoster virus (MR-Egger intercept = 0.053, p = 0.594). Additionally, Cochrane’s Q statistics results showed no heterogeneity for varicella (p = 0.906), but heterogeneity existed for zoster virus (p = 0.006) (Figure. 3 e-f).