2.4 Quality assessment
Quality assessment of RCTs was performed using the Cochrane
Collaboration’s tool for assessing risk of bias in randomized trials
(RoB-2), in which studies are scored as high, low, or unclear risk of
bias in 5 domains: selection, performance, detection, attrition, and
reporting biases. 12 Publication bias was
investigated, for outcomes that included all studies in this
meta-analysis, by funnel-plot analysis of point estimates according to
study weights.