3.4 Quality assessment
Individual bias appraisal is reported in Supplementary Table 1. Two studies lost points in domains related to deviation from the intended result, due to changes in the pre-specified plan.10,11One study was considered at high risk of bias.10 The remaining studies were considered low risk. In the analysis of the funnel chart, the outcome of adverse events was evaluated (Supplementary Figure 1). As illustrated in Supplementary Figure 1, a symmetrical distribution according to weight occurred, which converged to the combined effect of the treatment as the weights increased. There was no evidence of publication bias.