3.2 Pooled analyses of all studies
Regarding the lipid
panel, there was a statistically significant reduction in triglycerides
(MD -22.07; 95% CI -36.67 to -7.47; p=0.0006; I²=77%; Figure 2A) and
LDL (MD -7.10; 95% CI -13.40 to -0.80; p=0.03; I²=71%; Figure 2B) in
the FGF21 analog group in comparison to placebo. Moreover, there was an
increase in HDL levels in the intervention group (MD 6.28; 95% CI 3.34
to 9.22; p=0.0001; I²=80%; Figure 3A) compared to placebo. The
leave-one-out sensitivity analysis confirmed the result and reduced
heterogeneity with the removal of HARMONY (MD 4.75; 95% CI 3.38 to
6.12; I²=2%; Figure S13).