3.4 Quality assessment
Individual bias appraisal is reported in Supplementary Table 1. Two
studies lost points in domains related to deviation from the intended
result, due to changes in the pre-specified plan.10,11One study was considered at high risk of bias.10 The
remaining studies were considered low risk. In the analysis of the
funnel chart, the outcome of adverse events was evaluated (Supplementary
Figure 1). As illustrated in Supplementary Figure 1, a symmetrical
distribution according to weight occurred, which converged to the
combined effect of the treatment as the weights increased. There was no
evidence of publication bias.