Results
Among SARS-CoV-2 infection naïve subjects, BNT or CV significantly
increased the anti-S2 antibodies against Betacoronaviruses (OC43 and
MERS-CoV) but not Alphacoronaviruses (229E). The pre-vaccination
antibody response to the common cold human coronaviruses did not
negatively impact the post-vaccination antibody response to SARS-CoV-2.
Cross-reactive antibodies that binds to the S2 protein of MERS-CoV were
similarly detected from the convalescent sera of COVID-19 patients with
or without vaccination history. However, these anti-S2 antibodies do not
possess neutralizing activity in MERS-CoV pseudoparticle neutralisation
tests.