An method for the electrochemical synthesis of chalcogenosulfonates via
a tandem multi-component reaction has been developed. This method is
performed in an undivided cell without the requirement of external
oxidants, acids, and transition metals. A variety of indoles and
sulfinic acid sodium salts can be used in this method, and it is
effective for the late-stage modifications of complex molecules. Not
only thiosulfonates and selenosulfonates but also sulfonotelluroates
could be prepared, making this protocol a useful tool for the
devel-opment of new functional molecules. The afforded products are
promising for pesticide development.