Figure 1 . Functional distribution of proteins identified with differential expression in the ileum of NOD female mice treated with water containing 10 mgF/L or 0 mgF/L (control). Protein categories are based on Gene Ontology (GO) “Biological Process” annotation. Significance of terms (Kappa=0.04) and distribution according to the percentage of the number of genes. The protein accession number was provided by UniProt. GO was evaluated according to ClueGo plugin and Cytoscape 3.7.2 software
In the network generated by ClusterMarker2, when comparing the expression of altered proteins in the treated group (10 mgF/L) in relation to the control group (0 mgF/L), it was possible to observe many proteins interacting with High mobility group protein HMGI-C(P52927), Actin cytoplasmic 2 (P63260), Actin alpha skeletal muscle (P68134) and Microsomal triglyceride transfer protein large subunit (O08601) (Figure 2).