Conclusions
In summary, we have identified a relevant mouse model that mimics
COVID-19 in humans. We have leveraged this model to explore the complex
relationship between obesity and coronavirus disease severity. Our
findings suggest that obesity contributes to increased susceptibility to
severe coronavirus disease and may modulate tissue-specific responses.
Moreover, the identification of potential biomarkers shared with severe
COVID-19 cases in humans can be utilized to forecast disease outcomes,
assess risk levels, and prognose high-risk patients to enable timely
medical intervention. Future mechanistic studies are needed to elucidate
the precise roles of these biomarkers in coronavirus disease outcomes.