Introduction
Drug reaction with eosinophilia and systemic symptoms (DRESS) is also
known as drug-induced hypersensitivity (DiSH) or drug-induced delayed
multi-organ hypersensitivity syndrome. It is one of the severe cutaneous
adverse reactions to drugs (SCAR) syndrome, characterized by cutaneous
features of variable morphology and systemic organ involvement
[1,2]. Certain genetic predispositions and drug-virus interactions
are hypothesized to be the underlying pathogenesis of DRESS [2,3].
Herein, we report a case of a young female who developed DRESS with
acute respiratory failure due to sulfasalazine/hydroxychloroquine with
reactive Ebstein-Barr virus and human herpes virus-6.