Table-14. Tox21 Pathway Parameters for the ligands
Eritadenine (ERA), Ergosterol Peroxide (ERPO), Gallic Acid (GA), Pleuran (PLEU).
Androgen Receptor (NR-AR), Androgen Receptor Ligand Binding Domain (NR- AR- ABD), Antioxidant Response Element (SR-ARE), Aryl Hydrogen Receptor (NR- AhR), Aromatase enzyme (NR-Aromatase), ATPase family AAA domain-containing protein 5 (SR-ATAD5), Estrogen Receptor (NR-ER), Estrogen Receptor Ligand Binding Domain (NR-ER-LBD), Heat Shock Factor Response Element (SR-HSE), Mitochondrial Membrane Potential (SR-MMP), Peroxisome Proliferator- Activated Receptor Gamma (NR-PPAR-γ) and p53 binding site (SR-p53).
§ Negative or no toxicity (-), Positive or in probability of being actively toxic (+).