Results
From December 1, 2018 to November 30, 2020, there were 3460 patients with acute ICH enrolled in the CHEERY study and 3260 patients were included in the final analysis (figure 1). The demographic data were listed in table 1.
Patients’ average age was 61.9±12.3 during COVID-19 pandemic and 60.5±12.5 before COVID-19 breakout (P=0.001), respectively. COVID-19 pandemic was associated with lower percentage of the male (P=0.002), history of smoking (P=0.001) and drinking (P=0.017) (table 1).
During COVID-19 pandemic, patients more likely went to hospital directly by themselves (P<0.001), and took less time from the onset to admission (4(2,12) vs. 6(2,24) h, P<0.001) compared with before COVID-19. COVID-19 pandemic was also associated with increase of systolic blood pressure (BP) (171.3±29.2 vs. 164.3±28.7 mmHg, P<0.001), diastolic-BP (97.6±16.9 vs. 95.7±17.6 mmHg, P=0.002), NIHSS score (11.6±10.5 vs. 10.8±10.0, P=0.039), deep ICH (81% vs. 77%, P=0.010), hematoma volume (11.0(5.0,27.0) vs. 10.0(4.6,20.9)ml, P=0.009), IVH (16% vs. 14%, P=0.021) and fasting blood glucose (6.2(5.2,7.8) vs. 6.1(5.3,7.3) mmol/L, P=0.003) on admission (table 1). At 3 month, mRS score distribution was shown in figure 2. The three-month mortality was 23%, much higher than that of last year (14%) (P<0.001).
We then comparatively evaluated the outcomes. Table 2 shows COVID-19 pandemic was associated with increased risk of 3-month poor outcome (ORunadjusted = 1.244, 95%CI: 1.078-1.436; ORadjusted = 1.206, 95%CI: 1.043-1.395) and 3-month mortality (OR unadjusted = 1.772, 95%CI: 1.481-2.120; OR adjusted = 1.711, 95%CI: 1.428-2.050).