Gene Coding target and functions Variant/SNPs Risk of urticaria Influence on antihistamines efficacy(Drugs) Affects prognosis and severity Ref.
FCER1A
FcƐRIα: Initiating IgE mediated allergic reactions
rs2298805 (rs2298805A)
+
Increase
No reports
93
rs10908703 No reports
rs2494262 No reports
CACNA1C Alpha 1 c subunits in LTCC: Mediates Ca2+ influx rs58619945,A/G + No reports 94
RS216008 +( Desloratadine) No reports
RS7316246 +
ORAI1 ORAI1: Mediates Ca2+ influx rs3741596A Increase No reports No reports 98
rs12320939T Increase No reports No reports
rs3741595C Increase +( Desloratadine) No reports
C5AR1
C5aR: Regulate the complement C5a pathway
rs11673309 (—1330T/G)
Increase
+( Desloratadine)
No reports
99
CRTH2 G-protein-coupled, seven-transmembrane receptor family -466T>C Increase Increase dose No reports 102