Abstract
Antihistamines are widely used in
allergic diseases such as urticaria and allergic rhinitis, mainly by
reverse excited histamine and anti-allergic effects. Antihistamines are
generally safe, but there may be some adverse reactions like
cardiotoxicity, central inhibition, anticholinergic effects, etc. And
there are also individual differences in clinical practice. The concept
of individualized medicine has been deeply rooted in people’s minds
since it was put forward. In recent decades,
pharmacogenomics has been
developing rapidly, which provides new ideas for the occurrence of
individual medication. Gene polymorphism in the metabolic enzyme,
transports, and target receptors have been shown to affect the
application of antihistamines. Besides, recent evidence suggests that
genetic polymorphisms influence urticaria susceptibility and
antihistamine therapy. Here, we summarize current reports of this area,
aim to contribute to the future research and clinical guidance of
antihistamine personalized medicine.
Key words: Antihistamines, Pharmacogenomics, Individualized
medication, Urticaria, Adverse reactions