Figure legends
FIGURE 1. Gene polymorphism affects the efficacy and adverse
reactions of antihistamines. As a reverse agonist, antihistamine acts on
the histamine receptor to antagonize the histamine effect, exerting the
antihistamine and anti-allergic effect. Antihistamines complete the
process of absorption, distribution, metabolism and excretion under the
action of drug transporter and the cytochromes P450(CYPs). Mast cells,
one of the main histamine-releasing cells, express multiple receptors on
the surface. Polymorphisms of these receptor-related genes, histamine
receptor, transporter and metabolic enzyme related genes may affect drug
efficacy and adverse reactions.
Table 1. Effects of metabolic enzymes, drug transporters, and drug
target receptor gene polymorphisms on antihistamine drug therapy and
adverse reactions.