Monte Carlo simulation
To determine the factors that contribute to the clinical outcome at the
population level, Monte Carlo simulation was performed on a sample set
of laboratory and clinical parameters covering the full range, from
asymptomatic to severe disease, of outcomes (stages 1-7 [Figure 2])
[12, 13]. The histogram and cumulative data (Figure 3a)show the distribution of asymptomatic to severe outcomes. The Tornado
chart (Figure 3b ) shows the sensitivity of parameter to the
outcome in the selected range.