Data analysis
The mouse gene expression profile was analyzed by assessing Fold Change, and the threshold for screening up-regulated or down-regulated DE genes were Fold Change ≥ 2, P value < 0.05. Hierarchical clustering analysis by using R language. GO analysis and Pathway analysis were performed by using standard enrichment computational methods. The qPCR data were analyzed by GraphPad Prism 9 (California, USA). Student’s t-test was used for comparisons between the two groups. A p -value less than 0.05 indicated statistical significance.