Abbreviations:
TANs: tumor-associated neutrophils
PC: pancreatic cancer
TME: tumor microenvironment
ICIs: immune checkpoint inhibitors
PD-L1: programmed death ligand 1
CAR-T: chimeric antigen receptor T cell
MSI-H: microsatellite instability high
G-CSF: granulocyte colony-stimulating factor
IL-7:
interleukin-7
IL-6: interleukin-6
MDSCs: Myeloid-derived suppressor cells
NF-κB: nuclear factor-k-gene binding
TGF-β: transforming growth factor-β
IFN: i interferon
NET: neutrophil extracellular trap
PSCs: pancreatic stellate cells
CAFs: cancer-associated fibroblasts
TAMs: tumor-associated macrophages
CTL: cytotoxic T lymphocyte
HIF-1α: hypoxia-Inducible factor 1-alpha
LDHA: lactate dehydrogenase A
ARG1: arginase1