Study design and population
The study cohort consists of infants and toddlers who were referred to
our clinic with suspected peanut allergy. Some patients underwent an
oral food challenge (OFC) for routine diagnostics between 2007 and 2020.
Patient history, atopic comorbidities, OFC test results and objective
clinical symptoms were obtained from the ongoing EFA (Eczema and Food
Allergy) registry. Blood was collected from all patients in the frame of
routine diagnostics. Inclusion criteria for the analysis of
co-sensitization was age ≤ 2 years and specific IgE (sIgE) to peanut ≥
0.1 kU/l. Parents provided written informed consent. The study was
approved by the ethics committee of the Charité Universitätsmedizin,
Berlin.