Clinical reactivity to tree nuts according to probability curves
Clinical reactivity to hazelnut and cashew was estimated according to probability curves for Cor a 14- and Ana o 3-sIgE, respectively, as published in the literature (15, 16). As shown in Figure 3, five of the 101 peanut-sensitized infants and toddlers (5.0%) would have reacted with 90% probability to hazelnut and 14 (13.9%) to cashew. In total, 15.8% (n=16) of all peanut-sensitized children had an at least 90% predicted probability to be allergic to hazelnut and/or cashew. Of these, 18.8% (n=3) were known to be allergic to peanut, 75.0% (n=12) were clinical tolerant and for one the clinical relevance was not known (data not shown). Moreover, 13.9% (n=14) of the 101 infants and toddlers would have an > 50% probability to be hazelnut and 23.8% (n=24) to be cashew allergic (Figure 3).