Study design and population
The study cohort consists of infants and toddlers who were referred to our clinic with suspected peanut allergy. Some patients underwent an oral food challenge (OFC) for routine diagnostics between 2007 and 2020. Patient history, atopic comorbidities, OFC test results and objective clinical symptoms were obtained from the ongoing EFA (Eczema and Food Allergy) registry. Blood was collected from all patients in the frame of routine diagnostics. Inclusion criteria for the analysis of co-sensitization was age ≤ 2 years and specific IgE (sIgE) to peanut ≥ 0.1 kU/l. Parents provided written informed consent. The study was approved by the ethics committee of the Charité Universitätsmedizin, Berlin.