Statistical Analysis
All statistical analyses were performed using R version 4.2.0 (R Core
Team 2022). Categorical data are shown as absolute and relative
frequencies; continuous data are expressed as median and range. To test
if there were significant differences in sensitization patterns between
patients that were allergic or tolerant to peanut, chi-squared tests
were used (key basic assumptions of the test were not fulfilled
regarding sensitization to hazelnut and walnut). Wilcoxon tests were
performed to analyze if there were significant differences in sIgE
levels between peanut-allergic and peanut-tolerant patients. P-Values
were adjusted using the Bonferroni adjustment. A p-value of <
0.05 was considered to indicate a significant difference. In order to
determine the probability for a positive hazelnut food challenge by Cor
a 14‐sIgE and for a positive cashew food challenge by Ana o 3‐sIgE for
each patient, probability curves by Beyer et al. and Lange et al. were
utilized (15, 16). Since there is no probability curve available for
walnut, the individual risk for a positive OFC with walnut could not be
estimated.