Before PS Matching Before PS Matching Before PS Matching After PS Matching After PS Matching After PS Matching
Variables Anakinra (n=139) SoC (n=114) p value (OR) Anakinra (n=88) SoC (n=88) p value (OR)
Age, years, median (IQR) 71 (25) 65.5 (23) 0.09 70 (29) 66.5 (24) 0.6
Gender, male, n (%) 72 (51.8) 45 (39.5) 0.05 (3.8) 40 (45.5) 41 (46.6) 0.9
Duration of hospitalisation (days), median (IQR) 11 (12) 9 (7.3) 0.03 10 (13) 10 (9) 0.8
Comorbidities, n (%)
Diabetes mellitus 36/137 (26.3) 39 (34.2) 0.17 27 (30.7) 29 (33) 0.7
Hypertension 79/135 (58.5) 64 (56) 0.7 49/86 (57) 53 (60.2) 0.7
Coronary heart disease 24/135 (17.8) 24 (21) 0.5 19/86 (22) 19 (21.6) 0.9
Chronic renal failure 28 (20) 6 (5.3) 0.001 (11.9) 15/75 (19.2) 22 (25) 0.4
Chronic obstructive lung disease 22/136 (16.2) 19 (16.7) 0.9 14/86 (16.3) 14 (16) 1
Malignancy 16/138 (11.6) 8 (7) 0.2 6 (6.8) 8 (9.1) 0.6
Vaccination history 44/86 (51.2) 26/63 (41.3) 0.2 31/58 (53.4) 18/48 (37.5) 0.1
Disease severity, n (%)
NIH score 3 (severe) 54 (38.8) 68 (59.6) 0.001 (10.9) 36 (41) 46 (52) 0.1
NIH score 4 (critical) 85 (61.2) 46 (40.4) 52 (59) 42 (48)
Vaccination history, median (IQR) 2 (1) 2 (0) 0.9 3 (1) 2 (1.5) 0.13
mcHIS score, median (IQR) 3 (1) 3 (3) <0.001 3 (2) 3 (2) 0.5
Laboratory results
Neutrophil to lymphocyte ratio, median (IQR) 6.8 (8) 4.4 (4.44) 0.002 6.9 (8.2) 4.6 (5.4) 0.06
Hemoglobin (g/L), mean±SD 13.2±2.2 13.2±2 0.6 13.3±2.3 13.2±2 0.5
Creatinine (mg/dL), median (IQR) 0.9 (0.47) 0.83 (0.52) 0.5 0.84 (0.54) 0.9 (0.68) 0.4
Prokalsitonin (pg/dL), median (IQR) 0.2 (0.46) 0.16 (0.31) 0.7 0.18 (0.43) 0.18 (0.62) 0.5
C-reactive protein (mg/L), median (IQR)
1 116 (113) 100.3 (100.3) 0.4 115 (133) 107 (107) 0.9
2 148 (120) 126 (88) 0.012 141 (152) 141.2 (90) 0.7
3 11.4 (64) 13.1 (91) 0.5 10.4 (58.8) 14.5 (101) 0.2
Ferritin (pg/mL), median (IQR)
1 393 (592) 322 (423) 0.076 334.5 (590.5) 302 (371) 0.16
2 714 (969) 378 (660) <0.001 630 (811) 495 (873) 0.12
3 392 (590) 268 (480) 0.007 379 (427) 313 (630) 0.7
D-dimer (pg/mL), median (IQR)
1 1.2 (1.1) 0.85 (1.05) 0.04 1.24 (1.14) 1 (1) 0.05
2 4.1 (12.2) 2.25 (5) 0.002 2.75 (14.8) 2.7 (6.8) 0.4
3 1.4 (4.1) 1.14 (2.14) 0.15 1.37 (3.3) 1.2 (3.6) 0.9
Lactate dehydrogenase (U/L), median (IQR)
1 404 (220) 414 (229) 0.7 398.5 (219) 399.5 (210) 0.5
2 559 (266) 408 (237) <0.001 570 (259) 425 (269) <0.001
3 357 (231) 334 (170) 0.03 366.5 (204) 345.5 (195) 0.15
Outcomes, n (%)
Severe infection 19/128 (14.8) 26 (22.8) 0.1 13/82 (16) 25 (28.4) 0.05 (3.9)
Pneumothorax 3/134 (2.2) 0 0.1 2/86 (2.3) 0,00 0.15
Development of any thrombotic event 7 (5) 14 (12.3) 0.038 (4.3) 3 (3.4) 14 (15.9) 0.005 (7.9)
Pulmonary thromboembolism 4 (2.9) 11 (9.6) 0.023 (5.1) 3 (3.4) 11 (12.5) 0.026 (5)
Myocardial infarction 3 (2.2) 6 (5.3) 0.2 0 6 (6.8) 0.013 (6.2)
ICU requirement 55 (39.6) 25 (22) 0.003 (9) 33 (37.5) 24 (27.3) 0.2
Mortality 51 (36.7) 27 (23.7) 0.026 (5) 30 (34.1) 25 (28.4) 0.4