Patients with pulmonary thromboembolism before PSM Patients with pulmonary thromboembolism before PSM Patients with pulmonary thromboembolism before PSM Patients with pulmonary thromboembolism after PSM Patients with pulmonary thromboembolism after PSM Patients with pulmonary thromboembolism after PSM
Variables Yes (n=15) No (n=238) p value (OR) Yes (n=14) No (n=162) p value (OR)
Age, years, median (IQR) 71 (23) 68.5 (25) 0.09 68.5 (22) 69.5 (27) 0.9
Gender, male, n (%) 8 (53.3) 109 (45.8) 0.6 8 (57) 73 (45) 0.4
Duration of hospitalisation (days), median (IQR) 10 (5) 10 (10) 0.03 10.5 (5.75) 10 (10) 0.6
Comorbidities, n (%)
Diabetes mellitus 3 (20) 72/236 (30.5) 0.4 3 (21.4) 53 (32.7) 0.4
Hypertension 8 (53.3) 135/234 (57.7) 0.7 8 (57) 94/160 (58.8) 0.9
Coronary heart disease 5 (33.3) 43/234 (18.4) 0.16 5 (35.7) 33/160 (20.6) 0.2
Chronic renal failure 3 (20) 31 (13) 0.4 3 (21.4) 21 (13) 0.4
Chronic obstructive lung disease 3 (20) 38/235 (16.2) 0.7 3 (21.4) 25/160 (15.6) 0.6
Malignancy 2 (13.3) 22/237 (9.3) 0.6 2 (14.3) 12 (7.4) 0.4
Vaccination history 4/10 (40) 66/139 (47.5) 0.6 4/9 (44.4) 45/97 (46.4) 0.9
Disease severity, n (%)
NIH score 3 (severe) 2 (13.3) 120 (50.4) 0.005 (7.8) 1 (7) 81 (50) 0.002 (9.5)
NIH score 4 (critical) 13 (86.7) 118 (49.6) 13 (93) 81 (50)
Vaccination history, median (IQR) 2.5 (1.75) 2 (1) 0.03 2.5 (1.75) 2 (1) 1
mcHIS score, median (IQR) 4 (2) 3 (2) <0.001 4.5 (2) 3 (2) 0.002
Laboratory results
Neutrophil to lymphocyte ratio, median (IQR) 7.6 (12.2) 5.6 (5.7) 0.5 7.5 (12) 5.8 (6.5) 0.8
Hemoglobin (g/L), mean±SD 12.6±1.9 13.3±2.1 0.6 12.2±1.5 13.6±2.2 0.02
Creatinine (mg/dL), median (IQR) 0.94 (0.7) 0.84 (0.5) 0.5 1 (0.7) 0.85 (0.52) 0.6
Prokalsitonin (pg/dL), median (IQR) 0.13 (0.5) 0.2 (0.43) 0.7 0.1 (1.1) 0.2 (0.45) 0.7
C-reactive protein (mg/L), median (IQR)
1 110 (110) 108 (105) 0.4 114 (120) 107 (118) 0.6
2 212.5 (122) 138.6 (96) 0.012 216 (119) 136.5 (97.4) <0.001
3 87.4 (158) 11.6 (68) 0.5 91 (160) 11.6 (80.5) 0.1
Ferritin (pg/mL), median (IQR)
1 203 (413) 379 (543.5) 0.08 172.4 (223) 336 (544) 0.04
2 693.6 (739) 552 (863) <0.001 633 (800) 545.7 (853) 0.6
3 551.4 (614) 335.5 (487) 0.007 533.7 (699) 333 (486) 0.18
D-dimer (pg/mL), median (IQR)
1 1.1 (4.8) 1.17 (1.1) 0.04 0.75 (1.95) 1.2 (1.1) 0.4
2 31.8 (18.2) 2.7 (7.4) 0.002 33.4 (18.6) 2.6 (6.3) <0.001
3 22.3 (31.5) 1.2 (2.3) 0.15 27 (31) 1.2 (1.9) <0.001
Lactate dehydrogenase (U/L), median (IQR)
1 428.5 (207) 409 (219) 0.7 418 (154) 398 (207) 0.8
2 633 (426) 477 (282) <0.001 615.5 (468) 496 (282) 0.16
3 482 (495) 348 (171) 0.03 472 (517) 355 (166) 0.044
Outcomes, n (%)
Severe infection 6 (40) 39/227 (17.2) 0.028 (4.8) 6 (43) 32/156 (20.5) 0.055
Pneumothorax 1 (6.7) 2/233 (0.9) 0.046 (4) 1 (7) 1/160 (0.6) 0.03 (4.8)
Myocardial infarction 3 (20) 6 (2.5) <0.001 (12.6) 3 (21.4) 3 (1.9) <0.001 (15)
Treatment
Anakinra 4 (3) 135 (97) 0.023 (5.1) 3 (3.4) 85 (96.6) 0.026 (5)
SoC 11 (9.6) 103 (90.4) 11 (12.5) 77 (87.5)
ICU requirement 5 (33.3) 75 (31.5) 0.9 5 (35.7) 52 (32) 0.8
Mortality 8 (53.3) 70 (29.4) 0.052 8 (57) 47 (29) 0.03 (4.7)