Analysis Before PS Matching
We included 114 patients in SoC and 139 patients in Anakinra group into
the study. Baseline clinical and laboratory features of the patients
were described in table 1. Frequency of male gender (51.8% vs 39.5%,
p=0.05; Odds ratio [OR]: 3.8), chronic renal failure (CRF) (20% vs
5.3%, p=0.001; OR: 11.9), critical illness (61.2% vs 40.4%, p=0.001,
OR:10.9) were higher in Anakinra group than SoC. Additionally, median
(IQR) duration of hospitalization (11 [12] vs 9 [7.3] days;
p=0.03), mcHIS scores (p<0.001), baseline NLR (p=0.002) and
d-dimer levels (p=0.04), peak levels of CRP (p=0.012), ferritin
(p<0.001), d-dimer (p=0.002), LDH (p<0.001) levels
were higher in Anakinra receiving patients than SoC.
Development of any thromboembolic event (5% vs 12.3%, p=0.038; OR:4.3)
and PTE (2.9% vs 9.6%, p=0.023; OR:5.1) were lower in Anakinra group
than SoC. No patient experienced CVA and/or clinically evident DVT both
in two arms. Although severe infection, pneumothorax and MI were not
different between two arms (p=0.1, p=0.1, and p=0.2, respectively); ICU
admission (39.6% vs 22%, p=0.003; OR:9) and mortality (36.7% vs 27%,
p=0.026; OR:) were higher in Anakinra group compared to SoC before PS
matching analysis (table 1).
Patients experienced any thromboembolic event had longer duration of
hospitalization (p=0.03), higher vaccination counts (p=0.028), more
frequent CHD (p=0.001; OR:11.8), critical disease (p=0.001; OR:10.6),
higher mcHIS scores (p<0.001), lower NLR (p=0.002) and higher
baseline d-dimer levels (p=0.04), higher peak levels of CRP (p=0.012),
ferritin (p<0.001), d-dimer (p=0.002), and LDH
(p<0.001). Development of thrombosis was also higher in
patients had mortality (62% vs 28%, p=0.001; OR:10.4) in univariate
analysis (table 2). Patients developed PTE had longer duration of
hospitalization (p=0.03), higher vaccination counts (p=0.03), critical
disease (p=0.005; OR:7.8), higher mcHIS scores (p<0.001), and
higher baseline d-dimer levels (p=0.04), higher peak levels of CRP
(p=0.012), ferritin (p<0.001), d-dimer (p=0.002), and LDH
(p<0.001). Development of PTE was also higher in patients had
severe infection (p=0.028; OR:4.8), pneumothorax (p=0.046; OR:4), MI
(p<0.001; OR:12.6), and SoC (p=0.023; OR: 5.1) in univariate
analysis (table 3). In multivariate analysis, peak d-dimer levels
(p<0.001, OR:1.1, 95% Confidence interval [CI]:
1.05-1.16), critical illness (p=0.044, OR:9.5, 95% CI: 1.06-85.5), and
SoC (compared to Anakinra) (p=0.002, OR:11.2, 95% CI: 2.47-51.1) were
associated with development of any thromboembolic event (supplementary
table).