Patients with thrombosis before PSM Patients with thrombosis before PSM Patients with thrombosis before PSM Patients with thrombosis after PSM Patients with thrombosis after PSM Patients with thrombosis after PSM
Variables Yes (n=21) No (n=232) p value (OR) Yes (n=17) No (n=159) p value (OR)
Age, years, median (IQR) 71 (22) 68 (25) 0.09 71 (26) 69 (26) 0.5
Gender, male, n (%) 13 (62) 104(45) 0.1 10 (58.8) 71 (44.7) 0.3
Duration of hospitalisation (days), median (IQR) 11 (10) 9.5 (10) 0.03 11 (10) 10 (10) 0.4
Comorbidities, n (%)
Diabetes mellitus 7 (33.3) 68/230 (29.6) 0.7 5 (29.4) 51 (32) 0.8
Hypertension 13 (62) 130/228 (57) 0.7 10 (58.8) 92 (58.6) 1
Coronary heart disease 10 (47.6) 38/228 (16.7) 0.001 (11.8) 7 (41.2) 31 (19.7) 0.04 (4.1)
Chronic renal failure 4 (19) 30 (13) 0.4 4 (23.5) 33 (22) 0.9
Chronic obstructive lung disease 4 (19) 37/229 (16.2) 0.7 4 (23.5) 24 (15.3) 0.4
Malignancy 3 (14.3) 21/231 (9) 0.4 3 (17.6) 11 (7) 0.12
Vaccination history 5/13 (38.5) 65/136 (48) 0.5 4/10 (40) 45/96 (47) 0.7
Disease severity, n (%)
NIH score 3 (severe) 3 (14.3) 119 (51.3) 0.001 (10.6) 1 (6) 81 (61) <0.001 (12.5)
NIH score 4 (critical) 18 (85.7) 113 (48.7) 16 (94) 78 (49)
Vaccination counts, median (IQR) 3 (1.5) 2 (1) 0.028 2.5 (1.75) 2 (1) 1
mcHIS score, median (IQR) 4 (2) 3 (2) <0.001 4 (2) 3 (2) 0.001
Laboratory results
Neutrophil to lymphocyte ratio, median (IQR) 5.6 (10.5) 5.6 (5.8) 0.002 4 (10.8) 5.9 (6.7) 0.7
Hemoglobin (g/L), mean±SD 12.6±1.7 13.3±2.2 0.6 12.4±1.5 13.3±2.2 0.03
Creatinine (mg/dL), median (IQR) 0.94 (0.73) 0.84 (0.48) 0.5 0.94 (0.67) 0.85 (0.53) 0.7
Prokalsitonin (pg/dL), median (IQR) 0.2 (0.7) 0.2 (0.43) 0.7 0.12 (1.1) 0.2 (0.45)
C-reactive protein (mg/L), median (IQR)
1 118 (123) 108 (107) 0.4 110 (106) 107 (119) 0.9
2 212.5 (121) 137.5 (95) 0.012 212.5 (113) 135 (98) <0.001
3 87.4 (144) 11.5 (64) 0.5 121 (152) 11.4 (75) 0.014
Ferritin (pg/mL), median (IQR)
1 204.5 (603) 371 (545) 0.08 172 (223) 336 (544) 0.04
2 714 (735) 546 (867) <0.001 694 (735) 532 (853) 0.4
3 551.4 (695) 331.5 (483) 0.007 551 (680) 331.5 (483) 0.044
D-dimer (pg/mL), median (IQR)
1 1.44 (2) 1.15 (1.1) 0.04 0.75 (1.95) 1.2 (1.1) 0.4
2 21 (28) 2.7 (7.3) 0.002 23.8 (25) 2.56 (6.2) <0.001
3 5.6 (32.7) 1.2 (2.3) 0.15 19.7 (32) 1.18 (1.9) <0.001
Lactate dehydrogenase (U/L), median (IQR)
1 418 (268) 409 (215) 0.7 418 (154) 398 (207) 0.8
2 655 (487) 476 (271) <0.001 663 (540) 490 (277) 0.038
3 482 (518) 348 (169) 0.03 482 (506) 351 (164) 0.012
Outcomes, n (%)
Severe infection 7 (33.3) 38/221 (17.2) 0.07 7 (41) 31/153 (20.3) 0.05 (3.9)
Pneumothorax 1 (4.8) 2/227 (0.9) 0.1 1 (6) 1/157 (0.6) 0.054
Treatment
Anakinra 7 (5) 132 (95) 0.038 (4.3) 3 (17.6) 85 (53.5) 0.005 (7.9)
SoC 14 (12.3) 100 (87.7) 14 (82.4) 74 (46.5)
ICU requirement 10 (47.6) 70 (30.2) 0.1 8 (47) 49 (31) 0.17
Mortality 13 (62) 65 (28) 0.001 (10.4) 11 (64.7) 44 (27.7) 0.002 (9.8)