Background and Purpose
Aging is usually accompanied by mitochondrial dysfunction, reduced
energy levels, and cell death in the brain and other tissues.
Mitochondria play a crucial role in maintaining cellular energy through
oxidative phosphorylation (OXPHOS). However, OXPHOS is impaired as
mitochondrial oxygen supply decreases with age. We explored whether
pharmacologically increased oxygen diffusion by crocetin can restore
OXPHOS and help delay aging of brain and other vital organs.