Training and administration of the drug
The animals were trained to take the gelatin jelly voluntarily with
vehicle jelly pellets (10% gelatine, 1% sucralose). Most of the
animals (80%) liked the jelly and were trained for 15 days
(Supplementary Video SV1). Every third day, all the jelly pellets (10%
gelatine, 1% sucralose, and 25 mg ml-1 crocetin) were
prepared and stored at 4 °C, and were given to mice daily except Sundays
based on their body weight. All of the animals were kept under
observation until they finished their dosing pellets, with the majority
of them finishing in less than a minute.