Training and administration of the drug
The animals were trained to take the gelatin jelly voluntarily with vehicle jelly pellets (10% gelatine, 1% sucralose). Most of the animals (80%) liked the jelly and were trained for 15 days (Supplementary Video SV1). Every third day, all the jelly pellets (10% gelatine, 1% sucralose, and 25 mg ml-1 crocetin) were prepared and stored at 4 °C, and were given to mice daily except Sundays based on their body weight. All of the animals were kept under observation until they finished their dosing pellets, with the majority of them finishing in less than a minute.