Key Results
The aged mice treated with crocetin for four months displayed
significantly improved memory behavior, neuromuscular coordination, and
ATP and NAD+ levels in the brain and other vital organs, leading to an
increased median life span. The transcriptomic analysis of hippocampi
from crocetin-treated mice revealed that enhanced brain energy level was
caused by the upregulation of genes linked to OXPHOS, and their
expression was close to the expression in young mice. The chronic
treatment of aged astrocytes also showed improved mitochondrial membrane
potential and energy state of the cells.