Figure 3. Effect of Crocetin on electron transport chain in the
brain cells of old mice
(A) Gene Ontology (GO) enrichment analyses of genes expression in
hippocampi of control and crocetin-treated groups, all significant
differentially expressed pathways are shown in the dot plot, categorized
as BP (biological processes), CC (cellular component), and MF (molecular
function). (B) KEGG pathway analysis of differentially expressed genes
in hippocampi of control and crocetin groups. padj < 0.05 was
determined to be significant for this analysis. LCMS-based
quantification of (C) NAD+ and NADH, (D) ATP and AMP,
and (E) Glucose in the brain of mice from control and crocetin groups.
Data are shown as mean ± SEM and statistical significance was calculated
by comparing the control and crocetin groups. p-values were calculated
using a two-tailed unpaired student-t test and are shown for each bar
graph in the figure.