Safety
The incidence of any AEs when carotegrast methyl was combined with orally administered midazolam, prednisolone, atorvastatin, and intravenously administered midazolam, and for carotegrast methyl alone was 17/20 (85%), 5/20 (25%), 1/20 (5%), 16/20 (80%), 2/8 (25%), respectively. All AEs were mild in severity except for moderate upper limb fracture in combination with prednisolone and moderate influenza in combination with atorvastatin, all of which resolved except upper limb fracture. The most common AE was somnolence, which was reported in 17/20 (85%) of subjects receiving a concomitant oral midazolam and 15/20 (75%) of subjects receiving concomitant intravenous midazolam. AEs leading to discontinuation of the study were 1/20 (5%) in the combination with prednisolone and 1/20 (5%) in the combination with atorvastatin. Neither deaths nor the other serious AEs were reported.