Methods:
A total of 88 healthy volunteers
orally received carotegrast methyl 960 mg three times daily for 14 days.
A single oral (5 mg) or intravenous (0.017
mg kg-1)
midazolam, oral (5 mg) prednisolone, or oral (10 mg) atorvastatin was
administered before, with, and after carotegrast methyl treatment. When
the 90% confidence interval (CI) for the geometric mean ratios of the
pharmacokinetic (PK) parameters with coadministration with carotegrast
methyl (day 14) to those before carotegrast methyl administration was
between 0.80 and 1.25, no PK interaction were deemed.