Alveolar Epithelial Cell |
Primary Alveolar Epithelial Cells
(Human/Mouse) |
Resemble cells’ characteristics and physiological state;
preserve functionality and cell differentiation status. |
Unreliable
supply sources; difficult to isolate and cultivate (cannot be
continuously passaged, etc.); may lose original phenotype with
increasing culture time. |
Cell senescence, cell death, endoplasmic
reticulum stress, etc. |
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Human Lung Cancer Alveolar Epithelial Cell Line (A549 Cell Line) |
Easy to cultivate; exhibits characteristics of cancer cells, such as
rapid cell proliferation and immortalization; maintains its original
phenotype in culture. |
Alternative cell lines exhibit some
characteristics of AT2 cells, but their structure, barrier
properties, and cell phenotype are markedly different. |
EMT,cell
senescence, cell-cell communication, post-translational modifications
of proteins, etc. |
|
Mouse Alveolar Epithelial Cell Line (MLE-12 Cell Line) |
Retains many
characteristics of alveolar type II epithelial cells; expresses
surfactant proteins B and C (SP-B, SP-C); exhibits characteristics of
cancer cells, such as high proliferation rate and extended lifespan. |
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Rat Alveolar Epithelial Cell Line (RLE-6TN Cell Line) |
Exhibits
characteristics of alveolar type II cells; expresses chemotactic
cytokines similar to primary cultures of alveolar type II cells; does
not cause tumors in nude mice. |
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