Bronchial Epithelial Cell |
Primary Bronchial Epithelial Cells
(Human/Mouse) |
Most closely resemble natural epithelial
characteristics; maintain morphology, function, and expression of
pulmonary epithelial lineage features; retain potential for
proliferation, migration, and differentiation into various cell types. |
High cost of isolation and cultivation; may lose original phenotype
with increasing culture time. |
EMT, cell autophagy, cell senescence,
and apoptosis, etc. |
|
Human Bronchial Epithelial Cell Line (BEAS-2B Cell Line) |
Human
origin, physiological barrier characteristics, and easy cultivation;
exhibits immortalization; retains the ability for squamous
differentiation in response to serum; preserves epithelial cell
characteristics and terminal differentiation potential. |
May lose some
characteristics of primary cells; genetic material may undergo variation
during long-term passaging. |
EMT, post-translational modifications of
proteins, mitochondrial autophagy, etc. |
|
Human Bronchial Epithelial-Like Cell Line (16HBE Cell Line) |
Human
origin, physiological barrier characteristics, and easy cultivation;
retains differentiated epithelial morphology and maintains normal
epithelial function; capable of phagocytizing silica particles without
any ultrastructural changes; expresses basement membrane proteins and
type IV collagen, etc. |
|
|