Macrophage |
Primary Macrophages (Human/Mouse) |
Resemble cells’
physiological state; preserve characteristics and functions; ready for
immediate use. |
Tedious extraction process; unreliable sources; limited
in vitro expansion; some primary cells require induction for use. |
Inflammation, cell pyroptosis, macrophage activation,
etc. |
|
Human Peripheral Blood Monocyte Cell Line (THP-1 Cell Line) |
Similar
morphology and functional features as primary human monocytes (including
cell differentiation markers); in a macrophage-like state. |
Alternative
cell lines exhibit some characteristics of primary cells, but their
structure, barrier properties, and cell phenotype are markedly
different. |
Inflammation, cell autophagy, and cell apoptosis,
etc. |
|
Mouse Alveolar Macrophage Cell Line (MH-S Cell Line) |
Retains many
characteristics of alveolar macrophages, including typical macrophage
morphology; adhesive, phagocytic, esterase-positive, and
peroxidase-negative. |
|
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|
Mouse Macrophage Cell Line (RAW264.7 Cell Line) |
Circular or
elliptical, darker in color, firmly adherent; exhibits strong
phagocytic ability; enhanced pseudopod formation and climbing ability. |
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