Acknowledgements
We thank all the members in Akaike lab and Motohashi lab for their daily efforts and achievements in establishing a new landscape of pathophysiology regulated by the KEAP1-NRF2 system.
This work was supported by JSPS grant numbers 22K15504 (K.O.), 21H05258 (T.A., H.M.), 21H05263 (T.A.), 21H05264 (H.M.), 21H04799 (H.M.), and 22K19397 (T.A.), by JST-CREST grant number JPMJCR2024 (T.A.), and by AMED grant number JP21zf0127001 (T.A., H.M.).