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levels and proposed that reactivity & durability of cellular response ( CD8+ cells) can prevent severe disease against viral variant even when they escape from Nab. Equally, T-cell response at different time period has also been studied in healthy individuals. 4,16,17But there is paucity of data in immunocompromised individuals for sustained immune response especially with regards to T-cell-based immunity. Cirrhosis is associated with impairment of innate and adaptive immune system leading to acquired immunodeficiency. Both B and T-cell mediated immunity is hampered in form of B and T-cell depletion and dysfunction because of multifactorial causes like impaired production, proliferation and increased apoptosis.18,19 Hence, we selected patients of cirrhosis as immunocompromised population in our study. We studied different subset of T-cell memory cells along with antibody titer at baseline and at one year duration in vaccinated healthy individuals and patients with liver cirrhosis at one year to observe any difference in immune response.