Statistical analysis
Data are expressed as mean ± SD, median (interquartile range), or number
of patients (percentages) as appropriate. Normality of all continuous
data was confirmed with the Kolmogorov-Smirnov test. Group comparisons
for baseline characteristics, 2D and 3D echocardiographic parameters
used analysis of variance (ANOVA), Kruskal-Wallis test, chi-square test,
or Fisher exact test as appropriate. Univariate and multivariate linear
regression analyses were performed to identify MV 3D geometric variables
associated with 3D VCA. Degenerative variables of mitral valve
morphology previously shown to be associated with MR in MVP were tested.
Variables with P values ≤ 0.07 on univariate analysis were tested in the
multivariate linear regression with stepwise method. The association
between the TVi and other morphological variables was investigated with
Pearson correlation
analysis.
A receiver operating characteristic (ROC) curve was drawn to identify
the cutoff value of 3D VCA for MVPt+.