Conclusion
In summary, although RSV was more frequent in children, it can infect at
any age. Both subtypes (RSV-A and RSV-B) were found with B/B/A/B/B/A-B
pattern. Genomic analyses did not detect any novel mutations, but did
detect the emergence of new lineages with rare mutations in the data
available to date. These lineages may influence the preventive
treatments that are attempted.
This study provides an overview of the genetic variation of circulating
RSV strains in Asturias with the identification of new ON1 and BA9
lineages. Ongoing and long-term molecular epidemiological studies for
the detection of circulating and emerging genotypes in combination with
clinical data are needed to gain a better understanding of the
underlying genetic and antigenic mechanisms of RSV infection.
Acknowledgments: Project partially supported by Grupin
IDI/2021/000033