Figure 2. Network geometry for the efficacy outcome (a) and safety outcome (b). Each node represents one strain-specific intervention. The size of the node is proportional to the number of participants randomly assigned to the intervention, and the thickness of the lines is proportional to the number of trials comparing the two interventions. The largest node is placebo, with a total of 303 patients for the efficacy outcome and 370 patients for the safety outcome across all studies.