Efficacy outcome
Comparison Standardized Mean Difference (95% CI) Certainty of Evidence
LR and Placebo -0.53 (-1.02, -0.04) Low a
LS and Placebo -0.33 (-0.94, 0.27) Low a
LP1 and Placebo 0.33 (-0.84, 0.19) Moderate d
LP2 and Placebo -0.03 (-0.37, 0.32) Low a
MV1 and Placebo -0.12 (-0.44, 0.19) Low a
MV2 and Placebo 0.03 (-0.32, 0.37) Low a
MV3 and Placebo -0.28 (-0.90, 0.33) Very low a
Safety outcome
Comparison Relative Risk (95% CI) Certainty of Evidence
LR and Placebo 0.97 (0.79, 1.21) Moderate d
Mix and Placebo 1.39 (0.24, 8.09) Low e
LS and Placebo 0.91 (0.02, 43.99) Very low c
LP2 and Placebo 0.32 (0.01, 7.78) Very low b
MV1 and Placebo 0.72 (0.15, 3.58) Very low b
MV2 and Placebo 3.37 (2.48, 4.58) Low f
MV3 and Placebo 25.77 (1.63, 406.64) Low a