Sensitivity analysis
In the sensitivity analysis including only studies that used SCORAD, 3 postbiotic strains (LP, LR, LS) were evaluated in four studies. The network geometry is shown in Supplementary Figure 5a and the interval plot is shown in Supplementary Figure 5b. Compared to placebo, LR decreased the SCORAD value by 5.52 points (95% CI –10.46 to –0.58). Although statistically significant, results were not clinically significant since the mean difference (MD) was smaller than the MCID of 8.7 points. LS and LP had negative MD values indicating reduction in AD symptoms; however, the 95% CI are wide and inconclusive.
One dose-response-controlled trial was included in this NMA. Sensitivity analysis found no difference in results when using data from the low-dose and high-dose groups in reducing AD severity.7