Molecular Epidemiology of Rotavirus among Children in Western
Canada: Dynamic Changes in Genotype Prevalence in Four Consecutive
Seasons
Ran Zhuo1,2, †, Stephen B Freedman3,
Jianling Xie3, Carmen
Charlton1,2,4,5, Sabrina Plitt6,7,
Mathew A Croxen1,2,5, Vincent Li2,
Gillian AM Tarr8, Bonita Lee5,9,
Samina Ali5,9, Linda Chui1,2, Jasper
Luong1 and Xiaoli Pang1,2
1Department of Laboratory Medicine and Pathology,
University of Alberta, Edmonton, Alberta, Canada.
2Public Health Laboratory, Alberta Precision
Laboratories, Edmonton, Alberta, Canada.
3Sections of Pediatric Emergency Medicine and
Gastroenterology, Departments of Pediatrics and Emergency Medicine,
Alberta Children’s Hospital and Alberta Children’s Hospital Research
Institute, University of Calgary, Cumming School of Medicine, Calgary,
Alberta, Canada.
4Li Ka Shing Institute of Virology, University of
Alberta, Edmonton, Alberta, Canada
5Women and Children’s Health Research Institute,
University of Alberta, Edmonton, Alberta, Canada.
6School of Public Health, University of Alberta,
Edmonton, Alberta, Canada
7Centre for Communicable Diseases and Infection
Control, Public Health Agency of Canada, Ottawa, Ontario, Canada.
8Division of Environmental Health Sciences, School of
Public Health, University of Minnesota
9Department of Pediatrics, Faculty of Medicine &
Dentistry, University of Alberta, Edmonton, Alberta, Canada.
†Corresponding author: Dr. Ran Zhuo, Provincial
Laboratory for Public Health, Alberta Precision Laboratories, University
Alberta Hospital, WMC 2B2. 36, 8440-112 Street, Edmonton, AB, T6G 2J2,
Canada
Tel: 1-780-407-6829, Fax: 1-780-407-8984
E-mail: rzhuo@ualberta.ca
Keywords: rotavirus, genotype, whole-genome sequencing, molecular
epidemiology, pediatric, children, rotavirus vaccines
Running title: molecular epidemiology of rotavirus in Canadian children
pre- and post-rotavirus vaccine introduction
Abstract word count= 172,
Text word count= 3532,
no more than 50 references, n=50