Significance:
We identified dynamic changes in rotavirus molecular epidemiology in a
prospective cohort of children with acute gastroenteritis during pre-
and post- monovalent rotavirus vaccine (RV1) introduction era. While the
circulating rotavirus genotypes remained mostly unchanged, strain
predominance varied yearly. We found the emergent G12P[8] strain
predominantly infected older children and was the most common strain in
fully vaccinated children. Knowledge of the association between
rotavirus genotype diversity and AGE clinical severity is limited. Our
data suggest that other than RV1 related G1P[8] isolates, the
clinical severity of different rotavirus genotypes did not differ
significantly, thus emphasizing the need for rotavirus vaccines that
protects against all genotypes.