Figure 2. Deduced viral neutralization mechanism for 12-2A12. Figure 2a. Inhibition of the viral infection by blocking receptor-binding. Left panel, the structure of RBG-12-2A12 bound to rabies virus glycoprotein in the neutral-pH conformation. The nAChR-recognition region is highlighted and labeled. Right panel, a schematic model featuring the competition of the antibody against receptor binding. Figure 2b. Inhibition of the viral infection by inhibiting membrane-fusion. Left panel, alignment of 12-2A12 to a previously reported rabies virus glycoprotein structure in the acidic-pH conformation. Right panel, a schematic model featuring the inhibition of membrane fusion after endocytosis. Table 1 The SPR measurements for 12-2A12.