Introduction
Hereditary Spherocytosis (HS) is a common type of congenital hemolytic anemia, seen in 1 in every 2 000 patients. It is caused by genetic variations in erythrocyte membrane and cytoskeleton proteins such as spectrin, ankyrin, band 3, and band 4.2, which then cause the red blood cell (RBC) to have an abnormal shape. This can present in patients as pallor and jaundice. Patients may have anemia, abnormal peripheral blood smears, reticulocytosis and hyperbilirubinemia. HS is important to identify to ensure that the patient receives timely treatment to prevent serious outcomes of this disease, such as kernicterus in neonates, cholelithiasis and hemolytic crises.1