Introduction
Hereditary Spherocytosis (HS) is a common type of congenital hemolytic
anemia, seen in 1 in every 2 000 patients. It is caused by genetic
variations in erythrocyte membrane and cytoskeleton proteins such as
spectrin, ankyrin, band 3, and band 4.2, which then cause the red blood
cell (RBC) to have an abnormal shape. This can present in patients as
pallor and jaundice. Patients may have anemia, abnormal peripheral blood
smears, reticulocytosis and hyperbilirubinemia. HS is important to
identify to ensure that the patient receives timely treatment to prevent
serious outcomes of this disease, such as kernicterus in neonates,
cholelithiasis and hemolytic crises.1