References
  1. Sung H, Ferlay J, Siegel RL et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71:209–49.
  2. Yi et al. Epidemiological trends of women’s cancers from 1990 to 2019 at the global, regional, and national levels: a population-based study. Biomarker Research 2021 9:55.
  3. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15:10-7.
  4. Setiawan VW, Yang HP, Pike MC et al. Type I and II endometrial cancers: have they different risk factors? J Clin Oncol 2013;31:2607-18.
  5. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019;69:7-34.
  6. A. Oaknin, T. J. Bosse, C. L. Creutzberg et. al. Endometrial cancer : ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol 2022 09;33(9):860-877.
  7. PDQ Adult Treatment Editorial Board. PDQ Endometrial Cancer Treatment. Bethesda, MD: National Cancer Institute. Updated Feb 24 2022. https://www.cancer.gov/types/uterine/treatment-pdq. PMID: 26389270
  8. Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E. Endometrial cancer. Lancet 2016;387:1094-108.
  9. Matthews TJ, Hamilton BE. Delayed childbearing: more women are having their first child later in life. NCHS Data Brief 2009:1-8.
  10. Andreas Obermair et. al. Fertility-sparing treatment in early endometrial cancer: current state and future strategies. Obstet Gynecol Sci 2020;63(4):417-431.
  11. Michaela A. Onstad et. al. Addressing the role of obesity in endometrial cancer risk, prevention and treatment. J Clin Oncol 2016 34:4225-4230.
  12. Colquitt J.L. et. al. Surgery for weight loss in adults. Cochrane Review. The Cochrane Library 2014, Issue 8. http://www.chochranelibrary.com
  13. MacKintosh ML, Derbyshire AE, McVey RJ et al. The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk. Int J Cancer 2019;144:641–50.
  14. Syed I. Khalid et. al Association of Bariatric Surgery and Risk of Cancer in Patients With Morbid Obesity. Ann Surg 2022;275:1–6.
  15. Renehan AG, Zwahlen M, Egger M: Adiposity and cancer risk: New mechanistic insights from epidemiology. Nat Rev Cancer 2015;15:484-498.
  16. Park J, Morley TS, Kim M, et al: Obesity and cancer: Mechanisms underlying tumour progression and recurrence. Nat Rev Endocrinol 2014;10:455-465.
  17. Blakemore J, Naftolin F: Aromatase: Contributions to physiology and disease in women and men. Physiology (Bethesda) 2016;31:258-269.
  18. Simo R, Saez-Lopez C, Barbosa-Desongles A, et al: Novel insights in SHBG regulation and clinical implications. Trends Endocrinol Metab 2015; 26:376-383.
  19. Cavalieri E, Rogan E: The molecular etiology and prevention of estrogen-initiated cancers: Ockham’s Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity. Mol Aspects Med 2014;36:1-55.
  20. Nead KT, Sharp SJ, Thompson DJ, et al: Evidence of a causal association between insulinemia and endometrial cancer: A Mendelian randomization analysis. J Natl Cancer Inst 2015; 107-178.
  21. Mu N, Zhu Y, Wang Y, et al: Insulin resistance: A significant risk factor of endometrial cancer. Gynecol Oncol 2012;125:751-757.
  22. McCampbell AS, Broaddus RR, Loose DS, et al: Overexpression of the insulin-like growth factor I receptor and activation of the AKT pathway in hyperplastic endometrium. Clin Cancer Res 2006;12: 6373-6378.
  23. Ryu TY, Park J, Scherer PE: Hyperglycemia as a risk factor for cancer progression. Diabetes Metab J 2014;38:330-336.
  24. Kwon H, Pessin JE: Adipokines mediate inflammation and insulin resistance. Front Endocrinol (Lausanne) 2013;4:71.
  25. Syn NL, Cummings DE, Wang LZ et al. Association of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants. Lancet. 2021;397:1830–41.
  26. Ghiassi S, Morton JM. Safety and efficacy of bariatric and metabolic surgery. Curr Obes Rep. 2020;9:159–64.
  27. Arterburn DE, Telem DA, Kushner RF, Courcoulas AP. Benefits and risks of bariatric surgery in adults. JAMA. 2020;324:879–87.
  28. Sjöholm K, Carlsson LMS, Peltonen M et al. Association of bariatric surgery with cancer incidence in patients with obesity and diabetes: long-term results from the Swedish obese subjects study. Diabetes Care. 2022;45:444–450.
  29. Wiggins T, Antonowicz SS, Markar SR. Cancer risk following bariatric surgery—systematic review and meta-analysis of national population based cohort studies. Obes Surg. 2019;29:1031–9.
  30. Schauer DP, Feigelson HS, Koebnick C et al. Bariatric surgery and the risk of cancer in a large multisite cohort. Ann Surg. 2019; 269:95–101.
  31. Ishihara BP, Farah D, Fonseca MCM, Nazario A. The risk of developing breast, ovarian, and endometrial cancer in obese women submitted to bariatric surgery: a meta-analysis. Surg Obes Relat Dis. 2020;16:1596–602.
  32. Upala S, Sanguankeo A. Bariatric surgery and risk of postoperative endometrial cancer: a systematic review and meta-analysis. Surg Obes Relat Dis. 2015;11:949–55.
  33. Winder AA, Kularatna M, MacCormick AD. Does bariatric surgery affect the incidence of endometrial cancer development? A systematic review. Obes Surg. 2018;28:1433–40.
  34. MacKintosh ML, Derbyshire AE, McVey RJ et al. The impact of obesity and bariatric surgery on circulating and tissue biomarkers of endometrial cancer risk. Int J Cancer 2019;144:641–50.
  35. Barr CE, Ryan NAJ, Crosbie EJ et. al. Weight loss during intrauterine progestin treatment for obesity-associated atypical hyperplasia and early-stage cancer of the endometrium. Cancer Prev Res 2021;14:1041-1050.
  36. Chae SH, Shim SH, Lee SJ et. al. Pregnancy and oncologic outcomes after fertility sparing management for early stage endometrioid endometrial cancer. Int J Gynecol Cancer 2019;29:77-85.
  37. Gonthier C, Walker F, Luton D et. at. Impact of obesity on the results of fertility-sparing management for atypical hyperplasia and grade 1 endometrial cancer. Gynecol Oncol 2014;133:33-7.
  38. Moxthe LC, Sauls R, Ruiz M et. al. Effects of Bariatric Surgeries on Male and Female Fertility: A Systematic Review. J Reprod Infertil. 2020;21(2):71-86.
  39. Khan R, Dawlatly B, Chappatte O. Pregnancy outcome following bariatric surgery. The Obstetrician & Gynaecologist 2013;15:37–43.
  40. Denison FC, Aedla NR, Keag O, Hor K, Reynolds RM, Milne A, Diamond A, on behalf of the Royal College of Obstetricians and Gynaecologists. Care of Women with Obesity in Pregnancy. Green-top Guideline No. 72. BJOG 2018.