Figure 42 Schematic diagram for modification of SF with GMA (Silk-GMA)
and bioprinting of chondrocyte with Silk-GMA DLP 3D-printing
technology.[149]
Gelatin methacryloyl (GelMA) has been utilized as precursor for
3D-printed hydrogels because its biological activity, fast
photocrosslinking ability and temperature adjustable
viscosity,[150] whereas the poor mechanical
strength, low stability and non-self-healing behavior have hampered its
practical application in field of biomaterials. To deal with this
limitation, Mao et al.[151] synthesized a novel
host-guest supramolecular compound HGSM which based on the inclusion
interaction between cyclodextrin (CD) and adamantane (Ad), as exhibited
in Figure 43. The HGSM that has three “arms” of acrylates and GelMA
can photopolymerize to construct the hydrogel HGGelMA which possesses
the excellent mechanical and rapid self-healing properties due to the
non-covalent bonds. Compared with pure GelMA hydrogel, the compression
modulus of HGGelMA hydrogel increased by 525% which reached the level
of most human soft tissues. In addition, the HGGelMA hydrogel displayed
an excellent printability, The scaffold of 3D-printed HGGelMA hydrogel
has the exquisite and homogeneous porous structures, good
biocompatibility and histocompatibility with potential biomedical
applications.