5.1 Clinical manifestations
Serotonin syndrome occurs within hours of taking one or more drugs with a serotonergic effect. The classic triad of symptoms consists of: Neuromuscular abnormalities ( clonus, myoclonus, tremor, hyperreflexia, hypertonicity), autonomic hyperactivity (hyperthermia, tachycardia, hypertension, diarrhea) and altered mental status (agitation, confusion, anxiety, coma) 1,4,8. In table 321, these symptoms are tentatively categorized according to severity.