The utilization of cyclobutanones
as the synthon in transition metal catalysis has been made great
success. Because C(carbonyl)−C bond of cyclobutanones can be cleaved
through strain release. Despite those advancements, the main catalysts
in literature are Rh catalysts or Ni catalysts and the reaction with
C–H bond is still underdeveloped. Herein, we realized the first
palladium-catalyzed skeletal reorganisation of cyclobutanones invoving
successive cleavage of C(carbonyl)−C bonds and C−H bond cleavage, which
constitutes an rapid access to diverse
indanones.
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