Results
Following a single oral dosage of the rifampicin nanoformulation, the PK parameters were significantly different between the nanoparticle and conventional groups AUC (113.8 vs 58.6)***, MRT (16.2 vs 5.8)** and Ke (0.04 vs 0.10)*. Also SPECT/CT images revealed bio-distribution of nanoparticles in the distal portions of the intestine, which is consistent with our dosimetry analysis.