Animal pharmacokinetics and tissues distribution of PLGA
nanoparticles loaded with rifampicin
In an animal study, a peak plasma concentration of 3µg/ml was found at
12 h and a trough concentration of 0.3µg/ml post-single-dose oral
administration of rifampicin nanoparticles (Fig.6A). Tissue levels were
obtained high in lymph nodes at 4.5µg/ml at 3rd hour
and 12.6µg/ml at 6th-hour post single oral
administration, spleen drug concentration was found 3.2µg/ml at
6th-hour post-dosing (Fig.6B).