Animal pharmacokinetics and tissues distribution of PLGA nanoparticles loaded with rifampicin
In an animal study, a peak plasma concentration of 3µg/ml was found at 12 h and a trough concentration of 0.3µg/ml post-single-dose oral administration of rifampicin nanoparticles (Fig.6A). Tissue levels were obtained high in lymph nodes at 4.5µg/ml at 3rd hour and 12.6µg/ml at 6th-hour post single oral administration, spleen drug concentration was found 3.2µg/ml at 6th-hour post-dosing (Fig.6B).