Results
Following a single oral dosage of the rifampicin nanoformulation, the PK
parameters were significantly different between the nanoparticle and
conventional groups AUC (113.8 vs 58.6)***, MRT (16.2 vs 5.8)** and
Ke (0.04 vs 0.10)*. Also SPECT/CT images revealed
bio-distribution of nanoparticles in the distal portions of the
intestine, which is consistent with our dosimetry analysis.