Biodistrubution of PLGA loaded with radiolabeled rifampicin
compaired with conventional radiolabeled rifampicin
No focal uptake in any organ has been found in the conventional
rifampicin arm, but blood pool activity was present at all scanning time
points. Over the period, radioactivity in the body started to diminish
and was completely dull 24 hours after administering the dose (Fig. 8A).
Blood pool activity was not found in the nanoformulation group over 24
hours of post oral administration of single dose of 450mg rifampicin.
Nanoparticles were seen in different gut segments at different
pre-defined time points and finally accumulated in the large intestine.
(Fig. 8B). In the nanoformulation of the rifampicin arm, peri-splenic
uptake was seen in all healthy volunteers (Fig.8C),