Figure Legends
Figure 1. WM-related activation and deactivation and their
age-related changes.
A: lateral and medial maps of task-evoked activity in the “2back
-0back” condition, red/yellow indicates positive activity, blue/cyan
indicates negative activity; B: age-related changes of task-evoked
activity in the “2back -0back” condition, red/yellow indicates changes
in positive regions, blue/cyan indicates changes in negative regions; C:
scatter plots of brain activities of regions showing significant
age-related alterations. The results were corrected for multiple
comparisons at p < 0.05. Brain maps were generated using the
BrainNet viewer toolbox (Xia et al., 2013).
Figure 2. Regions showing age-related enhanced background
connectivity with dysfunctional task-evoked seed regions.
Upper: seed region in the inferior parietal lobule (IPL) and brain
regions where significant age impacts on background connectivity derived
from the IPL were found; Lower: seed region in the anterior cingulate
cortex (ACC) and brain regions where significant age impacts on
background connectivity derived from the ACC were found. The results
were thresholded at corrected p < 0.05.
Figure 3. Mediation models on age, regional activity,
background connectivity and WM performance.
A: Activation and background connectivity in the inferior parietal
lobule (IPL) mediated age-related effects on the accuracy rate (AR) of
the 2-back; B: Deactivation and background connectivity in the anterior
cingulate cortex (ACC) mediated age-related effects on the reaction time
(RT) of the 0-back. All coefficients are standardized and presented as
Estimate (Standard Error). Covariates included gender and years of
education and were not shown in the models. *** < 0.001, **
< 0.01, * < 0.05. CI, confidence interval.
Figure S1. Maps of background connectivity derived from seed regions.
A: Group-level connectivity map derived from the anterior cingulate
cortex (ACC); B: group-level connectivity map derived from the inferior
parietal lobule (IPL). Images were thresholded at uncorrected p
< 0.001.