Case
A 66-year-old man with recurred and nivolumab resistant esophageal
squamous cell carcinoma in left-side cervical and abdominal para-aortal
lymph node metastasis was treated with a total of 40 Gy (10 fractions)
of radiotherapy to the left-side cervical lymph node metastasis which
caused neck pain as a palliative treatment. Nivolumab was resumed the
day after completion of radiotherapy. At 3 months after radiotherapy
showed that the irradiated lesion in the left neck had regressed to a
scar-like appearance. Notably, the abdominal para-aortal lymph nodes
outside the irradiation area, which had previously tended to progress,
had also shrunk (abscopal effect). The T cell receptor and B cell
receptor (TCR/BCR) repertoire analysis before and after radiotherapy
revealed that radiotherapy caused the changes in the TCR/BCR repertoire.