Potential conflict of interests
Prof. Dr. Anke-Hilse Maitland-van der Zee has received research grants outside the submitted work from GSK, Boehringer Ingelheim and Vertex, she is the PI of P4O2 (Precision Medicine for more Oxygen), a public-private partnership co-funded by Health~Holland involving many private partners that contribute in-cash and/or in kind (Aparito, Boehringer Ingelheim, Breathomix, Clear, Danone Nutricia Research, Fluidda, MonitAir, Ncardia, Ortec Logiqcare, Philips, Quantib-U, Roche, Smartfish, SODAQ, Thirona, TopMD and Novartis), and she has served in advisory boards for AstraZeneca, GSK and Boehringer Ingelheim with money paid to her institution. Moreover, Dr. George Downward’s, Lizan Bloemsma’s and Yolanda de Wit’s conflicts of interest relates to the funding structure of P4O2 (public-private). The other authors declare no conflict of interests.