Correlation between DNA methylation level and chronological age
For each location, multiple CpGs showed significant correlations between
methylation level and age (4, 4, 3, and 2 CpGs for SLC12A5 ,POU4F2 , VGF , and SCGN , respectively; Supplementary
Figures S_R2_1, 2, 3, and 4). The CpGs that showed the strongest
correlations with age for each location are shown in Figure 2 (SLC12A5:
correlation coefficient [cor] = 0.98, p < 0.001; POU4F2:
cor = 0.94, p < 0.001; VGF: cor = 0.90, p < 0.001;
SCGN: cor = 0.90, p < 0.001). All results, including the
methylation levels of the remaining CpGs, are shown in Supplementary
Figures S_R3_1, 2, 3, and 4.